TABLE 1.
Demographic and clinical variables.
| TRD-MDD-P (n = 17) |
TRD-BD-P (n = 18) |
P-value | |
| Sex | 0.40743 | ||
| Female | 9 (52.9%) | 12 (66.7%) | |
| Male | 8 (47.1%) | 6 (33.3%) | |
| Mean age in years (SD) | 51.2 (11.1) | 46.3 (17.4) | 0.32661 |
| Mean body mass index (SD) | 27.2 (6.2) | 27.4 (6.5) | 0.94381 |
| Mean number of depressive episodes (SD) | 2.6 (2.2) | 6.5 (3.6) | 0.00082 |
| Mean duration of depressive episode in weeks (SD) | 23.9 (19.5) | 28.7 (32.1) | 0.83012 |
| Bipolar disorder type I | 0 (0.0%) | 12 (66.7%) | <0.00013 |
| Bipolar disorder type II | 0 (0.0%) | 6 (33.3%) | 0.00893 |
| Comorbidities | |||
| Hypertension | 7 (41.2%) | 5 (27.8%) | 0.40393 |
| Diabetes | 1 (5.9%) | 1 (5.6%) | 0.96683 |
| Epilepsy | 1 (5.9%) | 3 (16.7%) | 0.31623 |
| Hypercholesterolemia | 3 (17.6%) | 1 (5.6%) | 0.26113 |
| Other | 4 (23.5%) | 6 (33.3%) | 0.52113 |
| Co-existing treatment | |||
| Tricyclic antidepressants | |||
| Amitryptyline | 2 (11.8%) | 0 (0.0%) | 0.13403 |
| Clomipramine | 3 (17.6%) | 0 (0.0%) | 0.06233 |
| Selective serotonin reuptake inhibitors | |||
| Fluvoxamine | 0 (0.0%) | 1 (5.6%) | 0.32413 |
| Paroxetine | 2 (11.8%) | 2 (11.1%) | 0.95163 |
| Fluoxetine | 4 (23.5%) | 4 (22.2%) | 0.92673 |
| Sertraline | 4 (23.5%) | 4 (22.2%) | 0.92673 |
| Citalopram | 1 (5.9%) | 1 (5.6%) | 0.96683 |
| Escitalopram | 2 (11.8%) | 0 (0.0%) | 0.13403 |
| Selective serotonine-noradrenaline reuptake inhibitors | |||
| Venlafaxine | 6 (35.3%) | 5 (27.8%) | 0.63213 |
| Duloxetine | 2 (11.8%) | 1 (5.6%) | 0.51193 |
| Other antidepressants | |||
| Mirtazapine | 5 (29.4%) | 2 (11.1%) | 0.17613 |
| Mianserin | 0 (0.0%) | 1 (5.6%) | 0.32413 |
| Trazodone | 1 (5.9%) | 0 (0.0%) | 0.29653 |
| Bupropion | 1 (5.9%) | 2 (11.1%) | 0.58083 |
| Vortioxetine | 1 (5.9%) | 0 (0.0%) | 0.29653 |
| Antipsychotics | |||
| Aripiprazole | 1 (5.9%) | 5 (27.8%) | 0.08583 |
| Quetiapine | 4 (23.5%) | 8 (44.4%) | 0.19263 |
| Olanzapine | 2 (11.8%) | 6 (33.3%) | 0.12883 |
| Zuclopentixol | 1 (5.9%) | 0 (0.0%) | 0.29653 |
| Risperidone | 0 (0.0%) | 1 (5.6%) | 0.32413 |
| Mood stabilizers | |||
| Lithium | 1 (5.9%) | 8 (44.4%) | 0.00913 |
| Valproate | 2 (11.8%) | 6 (33.3%) | 0.12883 |
| Lamotrigine | 3 (17.6%) | 7 (38.9%) | 0.16443 |
1t-Student; 2U Mann–Whitney; 3Chi-squared; SD, standard deviation; TRD-MDD-P, treatment resistant major psychotic depression; TRD-BD-P, treatment resistant bipolar psychotic depression.