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. 2023 Jul 11;14:1205741. doi: 10.3389/fimmu.2023.1205741

Figure 2.

Figure 2

Identification of differentially expressed CRGs in patients with TB. (A) The expression levels of CRGs were presented in the heatmap. A total of 11 CRGs were identified as differentially expressed cuproptosis genes. (B) The expression levels of 11 CRGs were exhibited between control and TB groups in boxplots. The expressions of NFE2L2, NLRP3, ATP7B, SLC31A1, MTF1, and DLD were upregulated; LIAS, LIPT1, DLAT, GLS, and DBT were downregulated in TB patients. (C, D) Correlation analysis of 11 differentially expressed CRGs. Red and green colors respectively represent positive and negative correlations. Significant positive correlations were found between NFE2L2 and MTF1, LIPT1 and DLAT, DLD and DLAT, as well as GLS and DBT (*p<0.05, **p<0.01, ***p<0.001).