Figure 3.

Analysis of immune cell infiltration in patients with TB. (A) CIBERSORT analysis revealed differences in the abundance of 22 infiltrating immune cell types between the TB and control groups. (B) The differences in immune infiltration between control and TB groups are shown in the boxplot. CD8+ T cells, resting memory CD4+ T cells, and follicular helper T cells were significantly decreased, while monocytes, M0, M1, and M2 macrophages, activated dendritic cells, eosinophils, and neutrophils were increased in the TB group (C) Correlation analysis between 11 differential CRGs and infiltrated immune cells. Resting dendritic cells, eosinophils, M0, M1, and M2 macrophages, activated mast cells, resting mast cells, monocytes, neutrophils, activated NK cells, resting NK cells, plasma cells, activated memory CD4+ T cells, resting memory CD4+ T cells, naïve CD4+ T cells, CD8+ T cells, follicular helper T cells, gamma delta T cells, and T cells regulatory (Tregs) were associated with CRGs. *p<0.05, **p<0.01, ***p<0.001.