Figure 6.

Biological functions and pathway activities between two CRG clusters. (A) Differences in biological functions between Cluster 1 and Cluster 2 samples ranked by t-value of GSVA method. Lipopolysaccharide-mediated signaling, regulation of myeloid cell differentiation, and protoporphyrinogen IX metabolic process were significantly enriched in Cluster 1. Cerebellar Purkinje cell granule cell precursor cell signaling involved in the regulation of granule cell precursor cell proliferation, neuropeptide hormone activity, and positive regulation of gastrulation were significantly enriched in Cluster 2.(B) Differences in hallmark pathway activities between Cluster 1 and Cluster 2 samples ranked by the t-value of the GSVA method. Chronic myeloid leukemia, apoptosis, and neurotrophin signaling pathways were significantly enriched in Cluster 1. Olfactory transduction, taste transduction, maturity-onset diabetes of the young, retinol metabolism, and neuroactive ligand-receptor interaction were significantly enriched in Cluster 2.