Table 1. Results of clinical chemistry measurements in sera of female mice with 3 different doses of Oncaspar.

Parameters	NL NaCL	FL NaCL	NL Oncaspar 2700	FL Oncaspar 2700	NL Oncaspar 4050	FL Oncaspar 4050	NL Oncaspar 5400	FL Oncaspar 5400
Markers of liver toxicity:
ALT (U/L)	54.25±18.55	54.25±12.71	47.80±3.96	61.25±14.55	53.20±8.76	54.00±7.27	53.80±15.06	59.40±16.13
ALP (U/L)	142.00±7.62	120.50±7.77	112.40±10.09 ⁎⁎	158.80±15.17 †††	126.40±5.86	136.60±12.12	122.40±6.69	140.00±10.37
TBIL (mmol/L)	6.20±5.31	5.60±4.93	6.20±1.30	5.40±4.51	5.60±1.52	5.00±2.65	11.40±2.30	8.20±1.64
TP (g/dL)	4.92±0.19	4.83±0.40	4.24±0.17 ⁎⁎⁎	4.10±0.24 †††	4.18±0.15 ⁎⁎⁎	3.90±0.17 ††††	4.10±0.17 ⁎⁎⁎⁎	3.84±0.17 ††††
Markers of kidney toxicity:
CK (U/L)	336.33(391.59)	136.00±60.85	161.40±72.06	200±87.73	62.50±16.78	108.50±36.06	96.33±19.66	330.60±163.63
BUN (mmol/L)	6.54±0.77	7.95±1.44	10.14±0.68 ⁎⁎⁎⁎	7.36±1.06	9.32±0.99 ⁎⁎	10.00±1.15	9.70±1.01 ⁎⁎⁎	7.10±0.72
CREA (mmol/L)	17.20±2.95	16.00±1.83	22.80±0.84 ⁎⁎⁎	19.00±2.55	18.00±1.00	19.60±2.51	20.20±1.92	18.60±1.14
Markers of pancreatic toxicity:
Lipase (U/L)	957.50±10.61	892.50±2.12	781.00±30.70	603.00±12.90 ††	780.20±129.33	557.33±54.37 †††	680.25±54.89 ⁎⁎	630.40±94.23 ††
Other serum parameters:
Glucose (mmol/L)	10.84±1.68	12.80±3.51	7.45±1.48	7.75±2.20 †	8.65±1.82	9.88±1.56	9.20±1.42	9.28±1.32
Triglycerides (mmol/L)	0.91±0.23	1.43±0.50	1.35±0.32	1.14±0.46	1.25±0.17	1.61±0.16 ⁎⁎	1.58±0.15 ⁎⁎	0.97±0.11

Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total bilirubin (TBIL), Total protein (TP), Creatine kinase (CK), Blood urea nitrogen (BUN), Creatinine (CREA). ^⁎ Significant compared to NL NaCl group. ^† Significant compared to FL NaCl group. Means±SD. NL= normal liver, FL= fatty liver. ^**, ^††p < 0.01, ^***, ^††† p < 0.001, ^****, ^††††p < 0.0001.