Table 2. Results of clinical chemistry measurements at day 4 in sera of male mice treated with L-asparaginase.
| Parameters | NL NaCL+L-C | FL NaCL+L-C | NL L-asparaginase + NaCL | FL L-asparaginase + NaCL | NL L-asparaginase + L-C | FL L-asparaginase + L-C |
|---|---|---|---|---|---|---|
| Markers of liver toxicity: | ||||||
| ALT (U/L) | 48.13±8.03 | 52.75±13.49 | 49.33±12.00 | 58.11±21.20 | 50.13±11.87 | 119.63±93.08 |
| ALP (U/L) | 90.80±11.12 | 102.11±26.22 | 88.20±5.33 | 93.75±9.55 | 97.50±9.14 | 97.40±15.12 |
| TBIL (mmol/L) | 6.80±1.87 | 5.89±3.14 | 6.90±0.88 | 7.20±2.57 | 7.10±1.10 | 6.70±2.71 |
| TP (g/dL) | 4.89±0.25 | 5.01±0.36 | 5.02±0.24 | 5.23±0.18 | 5.09±0.28 | 5.36±0.26 |
| Markers of kidney toxicity: | ||||||
| CK (U/L) | 199.50±128.71 | 105.50±47.62 | 202.67±143.76 | 127.50±60.09 | 201.00± 130.10 | 167.63±81.27 |
| BUN (mmol/L) | 6.65±0.87 | 5.77±0.81 | 6.87±0.81 | 5.55±0.80 ++ | 7.58±0.67 | 5.18±0.45 xxxx |
| CREA (mmol/L) | 19.60±3.37 | 16.44±1.88 * | 17.20±1.55 | 17.30±1.25 | 18.60±1.58 | 15.10±0.74 xx |
| Markers of pancreatic toxicity: | ||||||
| Lipase (U/L) | 831.44±377.27 | 831.67±95.66 | 730.10±180.98 | 798.00±126.45 | 797.30±99.78 | 909.78±75.94 |
| Other serum parameters: | ||||||
| Glucose (mmol/L) | 11.56±3.89 | 11.72±2.21 | 10.46±2.44 | 10.64±2.04 | 11.26±2.13 | 11.83±3.22 |
| Triglycerides (mmol/L) | 0.96±0.36 | 0.97±0.29 | 0.84±0.29 | 1.02±0.17 | 1.11±0.22 | 0.98±0.21 |
Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total bilirubin (TBIL), Total protein (TP), Creatine kinase (CK), Blood urea nitrogen (BUN), Creatinine (CREA). * Significant to NL NaCl+L-C. + Significant to NL L-asparaginase +NaCl. x Significant to NL L-asparaginase +L-C. L-C= L-carnitine. NL= normal liver, FL= fatty liver. Means±SD. *, + , x p < 0.05, **, ++, xx p < 0.01, ****, ++++, xxxx p < 0.0001.