Table 3. Bodyweights, hematological and clinical chemistry parameters at day 28 in male mice treated with L-asparaginase.
| Parameters | NL NaCL+L-C | FL NaCL+L-C | NL L-asparaginase + NaCL | FL L-asparaginase + NaCL | NL L-asparaginase + L-C | FL L-asparaginase + L-C |
|---|---|---|---|---|---|---|
| % of body weight changes: | 4.0±1.4 | 11.10±2.7 * | 4.00±2.00 | 10.40±3.50 + | 3.00±3.20 | 8.50±4.70 x |
| WBCs: | 6.58±2.28 | 8.98±3.95 | 8.32±3.00 | 8.16±3.19 | 7.17±1.61 | 4.95±2.23 † |
| Markers of liver toxicity: | ||||||
| ALT (U/L) | 49.00±6.82 | 81.50±28.24 | 43.44±5.73 | 74.00±31.66 | 48.67±11.52 | 72.00±41.31 |
| AST (U/L) | 71.86±27.05 | 107.67±45.95 | 56.14±8.61 | 92.20±15.22 | 74.22±36.73 | 95.00±46.14 |
| ALP (U/L) | 82.38±8.14 | 104.22±58.67 | 84.78±8.91 | 106.75±8.97 | 93.11±9.99 | 107.00±32.89 |
| LDH ((U/L) | 279.00±37.40 | 445.60±148.50 | 278.86±65.03 | 399.80±92.09 | 340.38±122.76 | 347.00±138.80 |
| TBIL (mmol/L) | 7.25±1.04 | 7.44±3.28 | 6.44±0.73 | 6.75±1.49 | 6.44±0.88 | 6.44±3.00 |
| ALB (g/L) | 24.63±0.74 | 23.89±2.15 | 23.89±1.27 | 24.00±1.77 | 24.44±1.13 | 24.44±1.74 |
| TP (g/dL) | 4.83±0.10 | 5.02±0.27 | 4.76±0.13 | 4.95±0.23 | 4.86±0.19 | 5.04±0.27 |
| Markers of kidney toxicity: | ||||||
| CK (U/L) | 201.20±120.36 | 186.60(213.10) | 204.29±124.36 | 69.80±22.04 | 170.25(171.86) | 105.80±90.94 |
| BUN (mmol/L) | 6.81±0.67 | 5.78±0.52 | 6.98±0.70 | 5.06±0.32 +++ | 7.52±0.86 | 6.16±1.52 x |
| CREA (mmol/L) | 16.95±0.89 | 17.67±1.50 | 17.44±1.59 | 17.25±0.71 | 18.22±0.97 | 17.00±1.80 |
| Markers of pancreatic toxicity: | ||||||
| Lipase (U/L) | 829.38±91.47 | 908.00±91.39 | 849.56±48.78 | 996.88±407.59 | 870.00±46.72 | 911.67±115.20 |
| Amylase (U/L) | 2049.50±262.94 | 2719.00±310.88 *** | 1967.22±67.46 | 2814.88±473.88 ++++ | 2096.89±234.27 | 2626.50±463.02 xx |
| Other serum parameters: | ||||||
| Glucose (mmol/L) | 12.16±2.38 | 12.66±3.51 | 12.30±2.71 | 15.19±2.96 | 10.01±2.48 | 11.91±1.64 |
| Triglycerides (mmol/L) | 1.27±.022 | 1.19±0.42 | 0.94±0.19 | 0.99±0.35 | 1.08±0.35 | 0.92±0.23 |
| Cholesterol (mmol/L) | 2.24±0.09 | 4.48±1.26 **** | 2.22±0.14 | 4.93±1.10 ++++ | 2.12±0.29 | 4.50±1.10 xxxx |
Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Lactate Dehydrogenase (LDH), Total bilirubin (TBIL), Albumin (ALB), Total protein (TP), Creatine kinase (CK), Blood urea nitrogen (BUN), Creatinine (CREA). * Significant to NL+NaCl. † Significant to FL+NaCl. + Significant to NL L-asparaginase+NaCl. x Significant to NL L-asparaginase+L-C. L-C= L-carnitine. NL= normal liver, FL= fatty liver. Means±SD. *, † , + , x p < 0.05, **, †† , ++, xx p < 0.01, ***, ††† p < 0.001, ****, ††††, xxxx p < 0.0001.