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. 2023 Jul 11;14:1209056. doi: 10.3389/fimmu.2023.1209056

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Copyright © 2023 Liu, Li, Wei, Liu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple roles of MCs in colorectal tumours. The release of multiple factors, such as vascular endothelial growth factor, IFN, CXCL8, histamine, nitric oxide, and PGD2, as well as interactions with various populations of the immune system, including CD8+ T cells (130) and MDSCs (131), result in MCs shaping the tumour microenvironment (TME) in different ways and exerting antitumour and protumour effects depending on the context. MCs influence tumour aggressiveness through the release of trypsin and MMPs (111), among other substances. On the other hand, colon tumour cells influence the biological behavior of MCs by various means, such as the release of IL-33 (132) and the activation of Sigle (133), which is surface receptor of MCs.