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. 2023 Jul 11;16:1205265. doi: 10.3389/fnmol.2023.1205265

Figure 3.

Figure 3

Functional properties of the KCNQ2 variants coexpressed with WTKCNQ2. (A) Macroscopic current traces recorded in CHO cells transfected KCNQ2 variants with WTKCNQ2in a 1:1 ratio (1.5 μg:1.5 μg). Current scale, 250 pA; time scale, 200 ms. (B) The mean current densities of the KCNQ2 variants coexpressed with WT in a 1:1 ratio at +40mV. (C) Current–voltage relationships of KCNQ2 variants coexpressed with WTKCNQ2 in a 1:1 ratio determined from tail current amplitudes. Lines represent fits of a Boltzmann function. (D) Differences in activation of V0.5 were determined for the KCNQ2 variants and WTKCNQ2 in a 1:1 ratio (n = 8–15). Statistically significant differences *p < 0.05 versus WT KCNQ2.