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Overview of different inflammasomes. The structure and activation process of inflammasomes are depicted. Engagement of TLR, IL-1 and TNF receptors lead to activation of IKKs, which in turn results in activation of NF-κB signaling. Consequently, NF-κB activates inflammasomes. The NLRP3, AIM2 inflammasomes is strictly dependent on the adaptor ASC. In contrast, NLRP1 and NLRC4 possess a CARD domain and can recruit caspase-1 directly.
