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. 2023 Jul 11;14:1195572. doi: 10.3389/fimmu.2023.1195572

Figure 3.

Figure 3

Inflammasome in tumor promotion. (A) Activation of the NLRP3 inflammasome in cancer-associated fibroblasts links tissue damage with tumor-promoting inflammation in breast cancer progression and metastasis. (B–D): CAF-derived IL-1β facilitates lung metastasis. (B)Scheme of experiments analyzed in B-D. shIl1b 4T1 mammary carcinoma cells were orthotopically coinjected with WT NMFs (Il1b+/+ ) or with Il1b−/− NMFs into the right inguinal mammary glands of Il1b−/− female mice. (C) Growth curves of 4T1 tumors injected with WT NMFs (Il1b+/+ ) or with Il1b−/− NMFs. n = 10 mice per group. (D)Tumor weight at termination of experiment. n = 10 mice per group. (E) In NAFLD, NLRC4 contributes to M2 polarization, IL-1β, and VEGF production in TAMs, which promote metastatic liver tumor growth. (F) The pro-inflammatory cytokine IL-18 was critically involved in MM-associated inflammation and immunosuppression, and dysregulated IL-18 was a potential therapeutic target in the MM niche. The figures A-D are reprinted with permission from Ref (51). Copyright Nature Publishing Group. The figure E is reprinted with permission from Ref (62). Copyright WILEY. The figure F is reprinted with permission from Ref (55). Copyright Cell Press.