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. 2023 Jul 11;14:1191188. doi: 10.3389/fimmu.2023.1191188

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Copyright © 2023 Li, Yang, Wang, Chen and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglial Ccl2 levels positively correlate with Thompson classification of the degeneration level and pain score in SCI patients. Disc specimens from 30 healthy donors (CTL) and 30 SCI patients diagnosed with chronic spinal compression were examined. (A) Microglia were isolated from the disc specimens by digesting them into a single-cell fraction and subjecting them to fluorescence-activated cell sorting (FACS) for TMEM119, a specific marker for microglia. Representative flow charts were shown. (B) ELISA for Ccl2 on isolated spinal microglia. (C, D) The correlation between microglial Ccl2 protein and Thompson classification of the degeneration level (C, ɣ^2 =0.53, p<0.0001) or pain score (D, ɣ^2 =0.60, p<0.0001) was assessed. **p<0.01.