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. 2023 Jul 11;13:1231541. doi: 10.3389/fcimb.2023.1231541

Figure 3.

Figure 3

Associations of MRI features with gut microbiota at genus level. (A) Heatmap shows the correlation coefficient between structural MRI features and gut microbiota at genus level. (B) Eight region with significantly differential ALFF in CSVD patients compared with HCs (p < 0.05, Alphasim multiple comparison correction, voxel number: 70). Covariates were age, gender and years of education. (C) Heatmap shows the correlation coefficient between ALFF values in eight brain regions and gut microbiota at genus level. MRI, magnetic resonance imaging; CSVD, cerebral small vessel disease; HC, healthy control; P-WMH, periventricular white matter hyperintensities; D-WMH, deep white matter hyperintensities; EPVS, enlarged perivascular spaces; CMBs, cerebral microbleeds; Lis, lacunar infarcts; ALFF, amplitude of low-frequency fluctuation; SMA, supplementary motor area; DCG, median cingulate and paracingulate gyri; MFG, middle frontal gyrus; CAL, calcarine fissure and surrounding cortex; SOG, superior occipital gyrus; PCL, paracentral lobule. *P-value < 0.05; **P-value < 0.01.