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. 2023 Jul 11;13:1231541. doi: 10.3389/fcimb.2023.1231541

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Copyright © 2023 Shi, Zhao, Li, Zhao, Mao, Deng, Ji, Li, Gao, Zeng, Ma, Xi, You, Shao, Fang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic performance of gut microbiota at genus level for CSVD. (A) The coefficients of each gut microbiota in the LASSO model (1 = Parasutterella, 2 = Anaeroglobus, 3 = Megasphaera, 4 = Akkermansia, 5 = Collinsella, 6 = Veillonella). (B) The mean-squared error of LASSO model. (C) The significant difference in the relative levels of the composite biomarker between CSVD patients and HCs. (D) ROC curve of six gut microbiota at genus level for identifying CSVD. (E) ROC curve of the composite biomarker for identifying CSVD. CSVD, cerebral small vessel disease; HC, healthy control; LASSO, least absolute shrinkage and selection operator; ROC, receiver operating characteristic.