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. 2023 Jul 11;14:1163012. doi: 10.3389/fimmu.2023.1163012

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Copyright © 2023 Herd, Mellet, Mashingaidze, Durandt and Pepper

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contrasting healthy and HIV-affected bone marrow niches. HIV-associated changes are shown in red. HIV, human immunodeficiency virus; HSPC, haematopoietic stem/progenitor cell; MSC, mesenchymal stem/stromal cell; CAR cell, CXCL12-abundant reticular cell; CXCR4, C-X-C-motif chemokine receptor type 4; CXCL12, C-X-C-motif chemokine ligand 12; CD117, cluster of differentiation molecule 117; SCF, stem cell factor; TGF-β, transforming growth factor-beta; IL-6, interleukin-6; IFN-I, interferon type-I. Figure created in BioRender.com.