Table 2.
Deubiquitinases in bladder cancer tumorigenesis.
| DUBs | Function | Substrate | Pathway | Reference |
|---|---|---|---|---|
| OTUD5 | Promoting/oncogene | RNF186 | mTOR | (121) |
| OTUB1 | Promoting/oncogene | ATF6α | (122) | |
| SLC7A11 | (123) | |||
| MINDY1 | Promoting/oncogene | YAP | (119) | |
| UCHL5 | Promoting/oncogene | c-Myc | AKT/mTOR | (124) |
| Cisplatin resistance | β-catenin, c-Myc | (125) | ||
| USP24 | Promoting/oncogene | GSDMB | GSDMB/STAT3 | (126) |
| USP13 | Tumor suppressor | PTEN | (127) | |
| USP7 | Tumor suppressor | CCDC6 | (128, 129) | |
| USP8 | Promoting/oncogene | AUF1 | USP8/AUF1/RhoGD1β | (130) |
| USP38 | Tumor suppressor | METTL14 | (131) | |
| USP22 USP18,USP28 |
Promoting/oncogene | (132–135) |