Table 1.

Cardiovascular disease case definitions for validation in the reference set

Case definition
Case Definition 1	CAD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 410-414 AND ≥ 2 medications for ATC codes starting with C01, C07, C08, C09 OR CeVD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 430-438 OR PVD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 440.xx, or 443.xx
Case Definition 2	CAD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 410-414 OR CeVD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 430-438 OR PVD: ≥ 1 health condition, billing or encounter dx for ICD-9 codes 440.xx, or 443.xx
Case Definition 3	≥ 1 health condition, billing or encounter dx for ICD-9 codes 390-429, 430-448,458 OR ≥ 1 ATC code from medication table for B01A, C01A, C01B, C01CA17, C01D, C02AA, C02AB, C02C, C02D, C02L, C03, C04AD, C05BA, C07AA01, C07AA02 C07AA03, C07AA04, C07AA06, C07AA07, C07AA12, C07AB, C07AG, C07B, C07C, C08, C09, C10
Case Definition 4	≥ 1 health condition, billing or encounter dx within 1 year for ICD-9 codes 390-429, 430-448,458 OR ≥ 1 ATC code from medication table within 1 year for B01A, C01A, C01B, C01CA17, C01D, C02AA, C02AB, C02C, C02D, C02L, C03, C04AD, C05BA, C07AA01, C07AA02, C07AA03, C07AA04, C07AA06, C07AA07, C07AA12, C07AB, C07AG, C07B, C07C, C08, C09, C10

ATC, anatomical therapeutic chemical; CAD, coronary artery disease; CeVD, cerebrovascular disease; dx, diagnoses; ICD-9, International Classification of Diseases, ninth edition; Clinical Modification; PVD, peripheral vascular disease.