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. 2023 Jul 3;35:101708. doi: 10.1016/j.tranon.2023.101708

Fig. 6.

Fig 6

CVB inhibits the transcription and translation of its core targets. (A, B) mRNA expression of the core targets (BRCA1, POLD1, BLM, MSH2, MSH6 and PCNA) after CVB treatment (0, 80, and 160 μmol/L; 12 h). *P < 0.05, **P < 0.01 vs. the control group. The expression of the indicated factors was examined by RT‒qPCR. 18S RNA was used as the loading control. (C, D and E) The protein levels of the core targets (BRCA1, POLD1, BLM, MSH2, MSH6 and PCNA) were decreased after CVB treatment (0, 80, and 160 μmol/L; 24 h). The expression of the indicated factors was examined by Western blotting. β-actin was used as the loading control. *P < 0.05, **P < 0.01 vs. the control group.