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. 2023 Jul 20;18:3989–4005. doi: 10.2147/IJN.S417445

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© 2023 Yang et al.

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The solution-gel phase transition behavior. (A) Changes in the phase transition temperature of PPP hydrogel and GEM/PPP hydrogel with different concentrations of PPP copolymer. The blue dashed line corresponds to 37 °C. (B) Reversible solution-gel phase transition of GEM/PPP hydrogel (polymer concentration: 20 wt.%; GEM loading amount: 10 mg/mL) between 25 °C and 37 °C. (C) Injectability and rapid in situ gelation ability of GEM/PPP hydrogel (stained by Cy5.5). All data were obtained with 3 independent repeated experiments and presented as mean ± SD.