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. 2023 Jul 20;18:3989–4005. doi: 10.2147/IJN.S417445

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© 2023 Yang et al.

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The evaluation of anti-tumor efficacy and systemic toxicity through pathology. (A) Representative micrographs of major organs stained by H&E. Splenic hyperplasia was observed in the GEM (i.v.) and (i.t.) group, suggesting extramedullary hematopoiesis and splenic damage. Hepatic pericentral steatosis was observed in the GEM (i.t.) and ethanol (i.t.) group, indicating liver damage. No tissue damage was seen in GEM/PPP hydrogel (i.t.) group. (B) Representative micrographs of tumor sections stained by H&E, Ki-67 and TUNEL. Scale bar is 100 μm.