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. 2023 Jul 20;18:3989–4005. doi: 10.2147/IJN.S417445

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© 2023 Yang et al.

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Scheme 1 — Schematic representation of the sustained delivery of gemcitabine (GEM) through a biodegradable thermo-sensitive hydrogel (PLGA-PEG-PLGA, PPP). This injectable hydrogel allows for direct administration into pancreatic cancer via endoscopic ultrasound-guided fine needle injection (EUS-FNI) and facilitates sustained local drug delivery of GEM to exert an anti-tumor effect.