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. 2023 Jul 11;14:1156774. doi: 10.3389/fimmu.2023.1156774

Figure 6.

Figure 6

Histological analysis of adaptive immune cells in LSG tissues. (A, B) Statistical analysis of COX-IV expression based on RNA-sequencing data (A) and representative images of IHC staining for COX-IV (B) in human LSGs in the control and pSS groups (scale bar = 100 μm) (*, p < 0.05). (C–D) Statistical analysis of MMP9 expression based on RNA-sequencing data (C) and representative images of IHC staining for MMP9 (D) in human LSGs in the control and pSS groups (scale bar = 100 μm) (**, p < 0.01). (E, F) Statistical analysis of CD3 immune infiltration and ssGSEA scores based on RNA-sequencing data (E) and representative images of IHC staining for CD3 (F) in human LSGs in the control and pSS groups (scale bar = 100 μm) (**, p < 0.01). (G, H) Statistical analysis for CD8 immune infiltration and ssGSEA scores based on RNA-sequencing data (G) and representative images of IHC staining for CD8 (H) in human LSGs in the control and pSS groups (scale bar = 100 μm) (**, p < 0.01). (I, J) Statistical analysis of CD4 immune infiltration and ssGSEA scores based on RNA-sequencing data (I) and representative images of IHC staining for CD4 (J) in human LSGs in the control and pSS groups (scale bar = 100 μm) (*, p < 0.05). (K, L) Statistical analysis of Treg infiltration and ssGSEA scores based on RNA-sequencing data (K) and representative images of IHC staining for Foxp3 (L) in human LSGs in the control and pSS groups (scale bar = 100 μm) (**, p < 0.01). (M, N) Statistical analysis of B-cell infiltration and ssGSEA scores based on RNA-sequencing data (M) and representative images of IHC staining for CD20 (N) in human LSGs in the control and pSS groups (scale bar = 100 μm) (***, p < 0.001). (O, P) Statistical analysis of plasma cell infiltration and ssGSEA scores based on RNA-sequencing data (O) and representative images of IHC staining for CD38 (P) in human LSGs in the control and pSS groups (scale bar = 100 μm) (***, p < 0.001).