Figure 9.

Correlation between mitochondrial metabolic pathways and adaptive immune cells. (A) Schematic diagram demonstrating typical lymphocytic foci in the LSG, a feature of pSS. The glandular microenvironment undergoes metabolic reprogramming when triggered by the immune system, which may be a result of an inflammatory environment and may be directly triggered by mitochondrial dysfunction in some immune cells. (B) Correlation between the abundance of CD4⁺ T and CD8⁺ T cells and mitochondrial metabolic pathways. (C) Correlation between B and plasma cells and mitochondrial metabolic pathways. Statistical analysis was performed using the Mantel test, with the yellow line indicating p < 0.01 and the light yellow line indicating 0.01 < p < 0.05. The edge width corresponds to the r-value (Mantel’s test), and the edge colour indicated statistical significance. The relationship between variables was examined by estimating Pearson correlation coefficients. (D) Inset demonstrating a schematic diagram of each element involved in Figure 9A .