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. 2023 Jul 11;14:1207133. doi: 10.3389/fphys.2023.1207133

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Copyright © 2023 Wu, Wang, Liu, Wang and Rui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of Sirt6 in atherosclerosis. Sirt6 deacetylase activity suppresses TNFSF4 transcription, leading to atherosclerotic plaque formation. Sirt6 modulates Lin28b/let-7 pathway and retards atherosclerosis progression. Sirt6 depletion downregulates FOXM1 expression. Sirt6 exerts regulatory effect on NF-κB as well as its downstream signaling cascades to repress the inflammatory response in atherosclerosis. Sirt6 regulates the transcriptional activity of Srebp1/2, thus improving cholesterol homeostasis. Sirt6 inhibits Msr1 expression and reduces foam cell formation.