Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 11;14:1207133. doi: 10.3389/fphys.2023.1207133

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Wu, Wang, Liu, Wang and Rui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The molecular network of Sirt6 in cardiac ischemia/reperfusion (I/R) injury. Sirt6 activation disassembles CHMP2B accumulation via modulation of FoxO1-Atrogin1 signaling pathway and attenuates cardiac I/R injury. Sirt6 reduces myocardial susceptibility to I/R insult through preserving mitochondrial quality control via SIRT6-AMPK-PGC1α-AKT signaling pathway. Sirt6 inhibits apoptosis via NF-κB signaling. Sirt6 interacts with MiR-144 to reduce H/R-induced myocardial injury. Sirt6/FoxO3 complex upregulates the transcriptional activity of FoxO-dependent antioxidant genes to counteract I/R insult.