Table 2.

Electrospray technologies developed for cancer drug delivery.

Polymer	Cargo	Axial	Particle size range	Cell model	Animal model	Ref
PCL	Taxol	Mono	1–15 μm	C6 Glioma	−	[82]
PLGA	Paclitaxel	Mono	200 nm-10 μm	C6 Glioma	–	[83]
PLGA	Paclitaxel	Mono	13–17 μm	–	C6 Glioma cells subQ (BALB/c nude mice)	[84]
PLGA+Alginate	Paclitaxel	Mono (two-step)	10–15 μm (post-first step) 1.6–1.7 mm (post-second step)	C6 Glioma	C6 Glioma cells subQ (BALB/c nude mice)	[85]
EHEC	Fe3O4 NPs	Mono	1–10 μm	GL261 Glioma	–	[86]
PLA PLGA	PaclitaxelSuramin	Co (miscible)	10–20 μm	U87 Glioma	U87 Glioma cells subQ (BALB/c nude mice)	[87]
Gliadin or Gliadin-Gelatin	Cyclophosphamide	Mono	200–400 nm	MCF7 Breast	–	[88]
PLGA+PCL or PVP	Combretastatin A4 Doxorubicin	Co (miscible)	400–500 nm	B16-F10 Melanoma HUVECs	–	[89]
Silk Fibroin	Cisplatin	Mono	59–75 nm	A549 Lung L929 Fibroblasts	–	[90]
PLGA+Albumin	(5,10,15, 20-tetrakis(mesohydroxyphenyl)porphyrin) (mTHPP), Dasatinib	Mono	80–90 nm	U87MG Glioma	No disease (Wistar rats)	[91]
PLA	Gambogic-acid	Mono	70–7500 nm	–	H22 cells orthotopic	[92]
Silk Fibroin PVA	Doxorubicin	Co (miscible)	300–1800 nm	MDA-MB-231 Breast	MDA-MB-231 cells subQ (BALB/c nude mice)	[79]
Ecoflex®PEG	Docetaxel	Mono	360 nm	SKOV-3 Ovarian	SKOV-3 cells subQ (B6 nude)	[75]
PLGA	Paclitaxel Etoposide	Co (miscible)	1–4 μm	Saos-2 Osteosarcoma	–	[93]
Ac-DEX	cGAMP	Co (semimiscible)	1–3 μm	BMDCs	B16F10 in C57BL/6 mice Orthotopic E077 in C57BL/6 and 6(Cg)- Tmem173tm1.2Camb/J (Tmem173−/−) mice	[94]