Table 8.
Polymer | Cargo | Axial | Particle size range | Cell model | Animal model | Ref |
---|---|---|---|---|---|---|
PLGA Gelatin | Insulin-like growth factor | Co (immiscible) | 5 μm | MSCs SMCs |
– | [114] |
PLA PLGA | PDGF Simvastatin |
Co (semi-miscible) | 15–20 μm | – | Osteotomy repair (Sprague-Dawley rats) | [115] |
PLGA | Simvastatin | Mono | 1.6–8 μm | MG-63 osteoblasts | – | [116] |
PLA PLGA | PDGF Simvastatin |
Co (semi-miscible) | 18–21 μm | – | Osteotomy repair (Sprague-Dawley rats) | [117] |
Alginate CMC | R1 Embryonic stem cells | Co (miscible) | 285–345 μm | – | – | [118] |
PLGA | BSA SDF-1α |
Co (semi-miscible) | 4 μm | MSCs | – | [119] |
PCL Silk fibroin | Ascorbic acid Dexamethasone | Mono | 0.7–8 μm | ADSCs | – | [120] |
PLA PLGA | VEGF BMP-2 |
Co (semi-miscible) | 0.5–1.5 μm | MECs BMSCs |
Calvarial bone defects (Sprague-Dawley rats) | [121] |
PLGA | 3T3 fibroblasts | Co (immiscible) | ~10 μm | – | – | [122] |
PLGA | BMP-2 | Co (semi-miscible | 439 nm | – | Titanium screw implant model (Sprague-Dawley rats) | [123] |