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(A) Doxycycline (Dox)-inducible expression of RAGE in transgenic (TG) mice required a reverse tetracycline transactivator (rtTA) localized to respiratory epithelial cells via the human surfactant protein (hSP)-C promoter. The rtTA complexed with Dox and activated Tet-inducible RAGE expression. (B) Representative immunoblotting revealed increased expression of RAGE in RAGE TG mice fed Dox compared to Dox-exposed control animals. Actin was used as a loading control.
