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. 2023 Jul 15;11(3):33. doi: 10.3390/jdb11030033

Figure 2.

Figure 2

Hematoxylin and eosin staining revealed marked pulmonary simplification was observed in RAGE TG pup lungs compared to controls following RAGE induction from E0–15.5 (A,F), E0–16.5 (B,G), E0–17.5 (C,H), E0–18.5 (D,I), and E15.5–18.5 (E,J). Each lung sample from RAGE TG mice with dox administration since conception (F–I) contained marked tissue reduction (*) with only sporadic areas of distal lung parenchyma. While significant lung hypoplasia resulted from RAGE over-expression from conception, an intermediate phenotype that contained abundant parenchymal tissue prevailed when over-expression occurred from E15-5–E18-5 (J). Main image scale bars represent 50 μm and inset image scale bars represent 200 μm.