Table 1.

Impacts of miR-483-5p in human diseases.

Type of Disease	Expression Pattern	Tissue	Cell Lines	Targets	Function	References
Type 2 Diabetes	down	pancreatic islets	MIN6	SOCS3 ALDH1A3	Induce insulin secretion, inhibit glucagon secretion, and maintain β-cell identity	[16,24]
Obesity/ Diabetes	down	adipose	3T3-L1	ERK1 MeCP2	Promote adipogenesis	[41,42,43]
Fatty liver disease (NAFLD/ AFLD)	down	liver	HepG2	PCSK9 TIMP2 TGF-β PPARα SOCS3	Reduce lipid deposition and inhibit liver fibrosis	[32,33,38,39]
Diabetic nephropathy	down	Kidney tubule	HK2 TCMK-1	HDAC4 TIMP2 MAPK1	Prevent renal tubular damage and renal fibrosis	[44,45]
Alzheimer, Brain injury after cardiac arrest	down	neuron	Neonatal Fibroblasts, PC12	ERK1/2 TNFSF8 MeCP2	Promote mitochondrial biogenesis, inhibit ROS generation, protect neurological function, and regulate fetal brain development	[46]
Cardiovascular disease	up	serum, carotid bulb	AC16	MAPK3	Induced cell apoptosis and oxidative stress	[18,47,48,49]