Table 1.

Definitions by various societies and its differences

Variables	APASL [1]	NASCELD [6]	EASL [4]
Defined patient group	First episode in compensated cirrhosis or non-cirrhotic CLD	Patients with acutely decompensated cirrhosis, with or without prior episode(s) of decompensation	Acute decompensation in cirrhosis patient with or without prior decompensation
Acute insult	Hepatic only Variceal bleed is considered as insult if it results in liver failure	Extra-hepatic	Hepatic or extra-hepatic
		Variceal bleed is considered as precipitant
Organ failure	Liver-central to pathogenesis	Any of the 4	Any of 6
		Cardiac (shock), hepatic encephalopathy, renal (need for dialysis), respiratory (need for mechanical ventilation)	Liver/cardiac/renal/circulatory/coagulant/respiratory
Duration	Acute insult leading to development of ACLF with in 4 weeks	No specific duration specified	No specific duration specified
Definition basis	Liver involvement is the central cause and subsequently other extrahepatic organ failures follow	Existence of 2 or more organ system failures	Based on existence of 1 of the six organ failures and CLIF-C score is used to categorize
	AARC score is used to stratify
Mortality	Grade 1-13%	2 OF-49%	Grade 1-20%
	Grade 2-45%	3 OF-64%	Grade 2-30%
	Grade 3-86%	4 OF-77%	Grade 3-80%

ACLF, acute on chronic liver failure; APASL, Asian pacific Association for study of liver; NASCELD, North American Consortium for the Study of End-Stage Liver Disease; EASL, European association of study of liver; AARC, APASL ACLF research consortium score; MELD, Model for end stage liver disease; CLIF C-ACLF, chronic liver failure consortium acute-on-chronic liver failure; CLD, chronic liver disease; OF, organ failure.