Table 2.
Organ failures definitions
| Organ failure | Asian Pacific Association for the Study of the Liver | European Association for the Study of Liver-Chronic Liver failure organ failures definition Based on CLIF-C ACLF score | North American Consortium for Study of End-stage Liver Disease organ failures definition |
|---|---|---|---|
| Liver | Total bilirubin ≥5 mg/dL | Bilirubin >12 mg/dL | – |
| INR ≥1.5 | |||
| Coagulation | INR ≥1.5 | INR ≥2.5 | – |
| Kidney | AKIN criteria Creatinine: increase > 0.3 or 1.5-fold over 48 h to: >/= 0.7 & 1.5 | Creatinine level of ≥2.0 mg/dL or renal replacement | Need for dialysis or other forms of renal replacement therapy |
| Brain | HE (West-Haven) grade 3–4 | HE (West-Haven) grade 3–4 | HE (West-Haven) grade 3–4 |
| Circulation | – | Vasopressor usage (terlipressin and/or catecholamines) | Shock with MAP<60 mm of hg or drop of >40 mm of Hg from the baseline despite adequate fluid resuscitation |
| Respiration | PaO2/FiO2 of ≤200 or SpO2/FiO2 of ≤214 or mechanical ventilation | Need for mechanical ventilation |
Organ dysfunction defined as (coagulation–INR >1.5, Renal–creatinine [1.1–1.5 mg/dL], cerebral [HE grade I–II], circulatory–< Systolic BP < 70 mm of Hg, respiratory PaO2/FiO2 200–300).
CLIF C-ACLF, chronic liver failure consortium acute-on-chronic liver failure; INR, international normalised ratio; AKIN, acute kidney injury network; BP, blood pressure; HE, hepatic encephalopathy; MAP, mean arterial pressure.