(A) CLIF-SOFA Score

Organ/system	0	1	2	3	4
Liver (bilirubin, mg/dL)	<1.2	≥1.2 to ≤2.0	≥2.0 to <6.0	≥6.0 to <12.0	≥12.0
Kidney (creatinine, mg/dL)	<1.2	≥1.2 to <2.0	≥2.0 to <3.5	≥3.5 to <5.0	≥5.0
			or use of renal replacement therapy
Cerebral (HE grade)	No HE	I	II	III	IV
Coagulation (international normalized ratio)	<1.1	≥1.1 to <1.25	≥1.25 to <1.5	≥1.5 to <2.5	≥2.5 or platelet count ≤20×109/L
Circulation (mean arterial pressure, mm Hg)	≥70	<70	Dopamine ≤5 or dobutamine or terlipressin	Dopamine >5 or E ≤0.1 or NE ≤0.1	Dopamine >15 or E >0.1 or NE >0.1
Lungs
PaO2/FiO2 or	>400	>300 to ≤400	>200 to ≤300	>100 to ≤200	≤100
SpO2/FiO2	>512	>357 to ≤512	>214 to ≤357	>89 to ≤214	≤89

CLIF C-ACLF score 10×[0.033×Clif OFs+0.04×Age+0.63×Ln(WBC)–2].

CLIF C-ACLF, chronic liver failure consortium acute-on-chronic liver failure; HE, hepatic encephalopathy; NE, nor epinephrine; WBC, white blood cell count.