Table 3.
Factors predicting the presence of severe microvascular invasion
| Variable | Univariable analysis |
Multivariable analysis |
|||
|---|---|---|---|---|---|
| Odds ratio (95 % CI) | P-value | Odds ratio (95 % CI) | P-value | ||
| Clinical feature | |||||
| Age (≥60 years) | 0.990 (0.644–1.521) | 0.962 | |||
| Sex (male) | 1.156 (0.665–2.011) | 0.608 | |||
| Etiology (hepatitis B virus) | 0.685 (0.419–1.120) | 0.131 | |||
| Platelet (<100×109/L) | 0.424 (0.163–1.101) | 0.078 | |||
| PT-INR (>1.0) | 0.837 (0.534–1.314) | 0.440 | |||
| Albumin (<4.0 g/dL) | 1.423 (0.903–2.242) | 0.128 | |||
| Bilirubin (>1.0 mg/dL) | 1.662 (1.038–2.661) | 0.035* | 1.254 (0.728–2.159) | 0.415 | |
| AST (>30 U/L) | 1.590 (1.034–2.446) | 0.035* | 1.460 (0.888–2.401) | 0.136 | |
| ALT (>30 U/L) | 1.458 (0.943–2.255) | 0.090 | |||
| AFP (≥400 ng/mL) | 3.919 (2.384–6.443) | <0.001* | 2.749 (1.560–4.844) | <0.001* | |
| PIVKA-II (≥400 mAU/mL) | 3.945 (2.493–6.240) | <0.001* | 2.377 (1.348–4.193) | 0.017* | |
| MRI finding | |||||
| Tumor size (≥3 cm) | 3.233 (2.033–5.141) | <0.001* | 1.576 (0.892–2.786) | 0.118 | |
| Arterial peritumoral enhancement | 2.455 (1.548–3.892) | <0.001* | 1.156 (0.664–2.013) | 0.609 | |
| Non-smooth tumor margin | 4.139 (2.190–7.825) | <0.001* | 2.224 (1.115–4.434) | 0.023* | |
| Peritumoral hypointensity on HBP | 3.201 (2.061–4.973) | <0.001* | 1.321 (0.761–2.291) | 0.323 | |
| Satellite nodule | 5.290 (2.897–9.660) | <0.001* | 3.264 (1.622–6.567) | <0.001* | |
CI, confidence interval; PT-INR, prothrombin time-international normalized ratio; AST, aspartate aminotransferase; ALT, alanine aminotransferase; AFP, alpha fetoprotein; PIVKA-II, prothrombin induced by vitamin K absence-II; MRI, magnetic resonance imaging; HBP, hepatobiliary phase.
*
Indicates P<0.05.