Figure 4.

CSF sTREM2 levels increase with age and are the highest in the AD group. Higher CSF sTREM2 is associated with higher CSF levels of p-tau and total tau and lower cognitive performance. CSF sTREM2 can discriminate healthy from diseased subjects with a sensitivity of 65.81% and a specificity of 80.0%. AD, Alzheimer’s disease; CSF, cerebrospinal fluid; HC, healthy controls; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; p-tau, tau phosphorylated at epitope 181; sTREM2, soluble Triggering Receptor Expressed on Myeloid cells 2; “true −“ denotes specificity; “true +” denotes sensitivity; t-tau, total tau proteins.