Table 3.
CD8+ T cell outcomes in the eutopic endometrium.
| AUTHORS YEAR |
TOTAL (N) | ENDOMETRIOSIS (N) | CONTROLS (N) | UTERINE CYCLE PHASE (N) | ANALYZED SAMPLES OF THE TOTAL (N) | CD8+ T CELL FINDINGS IN ENDOMETRIOSIS VERSUS CONTROLS | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage I/II | Stage III/IV | Subfertility | Age (yrs)* | Diagnosis | Subfertility | Age (yrs)* | Proliferative | Secretory | Endometriosis | Controls | |||
| Ahn, 2016 | 16 | 0 | 8 | 8 | 33.1 ( ± 7.3) | Tubal ligation | 0 | 26 ( ± 5.8) | 0 | 16 | 8 | 8 | NO DIFFERENCE in the expression of CD8A gene. |
| Bulmer, 1998 | 60 | N/A | N/A | N/A | N/A | Non-endometrial pathology | N/A | N/A | 20 | 40 | 30 | 30 | NO DIFFERENCE in neither glandular nor surface intraepithelial CD8+ cells. |
| Bunis, 2022 | 105 | 24 | 47 | N/A | 20–50 | Tubal ligation/reanastomosis | 0 | 20–50 | 47 | 58 | 71 | 34 | INCREASED effector memory CD8+ T cell score across all cycle phases (FDR < 0.05, log2 fold change > 1). |
| Klentzeris, 1995 | 34 | 11 | 5 | 16 | 33.2 ( ± 1.6, 22–41) | Tubal ligation/reanastomosis | 0 | 35.4 ( ± 2.8, 24–40) | 0 | 34 | 16 | 18 | NO DIFFERENCE in precipitate area for CD8+ cells. |
| Mettler, 1997 | 143 | * | * | 143 | 29.8 (24–36) | Tubal factor infertility | 110 | 29.6 (24–35) | ** | ** | 253 | 110 | NO DIFFERENCE in CD8+ quantity per mm2 and no differences in lymphocyte aggregations. |
| Poli-Neto, 2021 | 59 | 16 | 43 | N/A | N/A | Healthy | N/A | N/A | 113 | 0 | 59 | 54 |
INCREASED effector memory CD8+ T cell score in mild and severe disease (p = 0.000; p = 0.027). DECREASED naive and central memory CD8+ T cell scores in in mild and severe disease (p = 0.001; p = 0.000 and p = 0.035; p = 0.782). |
| Wu, 2019 | 15 | 0 | 15 | N/A | 44.60 ( ± 2.57) | Non-endometrial pathology | N/A | 47.00 ( ± 4.04) | 30 | 0 | 15 | 15 | INCREASED CD8+ quantity per mm2 (p < 0.01). |
| Wu, 2021 | 67 | N/A | N/A | N/A | N/A | Healthy | N/A | N/A | 107* | * | 67 | 40 |
INCREASED CD8+ T cell score (CIBERSORT: p = 0.0033; MCP-counter: p = 0.00018; ImmuneCellAI: p = 7.2e-8). DECREASED naïve (p = 7.6e-5), central memory (p = 0.00076), and effector memory CD8+ T cells (p = 1.1e-6). |
| 18 | N/A | N/A | 9 | N/A | Healthy | 9 | N/A | 36* | * | 18 | 18 | INCREASED CD8+ T cell score in infertile women with endometriosis versus fertile women with endometriosis (p = 0.0019, AUC = 0.722). | |
| 40 | N/A | N/A | N/A | N/A | Healthy | N/A | N/A | 40* | * | 20 | 20 | INCREASED CD8+ cell ratio (p = 0.0132, AUC = 0.727). | |
| Zhong, 2021 | 180 | 20 | 62 | N/A | N/A | N/A | N/A | N/A | 204 | 0 | 112 | 68 |
NO DIFFERENCE in CD8+ T cell ratio. NO DIFFERENCE in CD8+ T cell ratios between mild and severe disease. |
* Mixed with early secretory.
** Up to 7 patients for every day of the menstrual cycle (28–29 days).
N/A, Not available; Age (yrs)*: Mean ± SD or Median (Range).