Table 4.
CD8+ T cell outcomes in the ectopic endometrium.
| FIRST AUTHOR, YEAR |
TOTAL (N) | ENDOMETRIOSIS (N) | CONTROLS (N) | UTERINE CYCLE PHASE (N) | ANALYZED SAMPLES OF THE TOTAL (N) | CD8+ T CELLS FINDINGS IN ECTOPIC ENDOMETRIUM COMPARED TO EUTOPIC AND HEALTHY ENDOMETRIUM | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage I/II | Stage III/IV | Subfertility | Age (yrs)* | Diagnosis | Subfertility | Age (yrs)* | Proliferative | Secretory | Eutopic | Ectopic | Controls | |||
| Ahn, 2016 | 16 | 0 | 8 | 8 | 33.1 ( ± 7.3) | Tubal ligation | 0 | 26 ( ± 5.8) | 0 | 16 | 8 | 8 | 8 | INCREASED expression of CD8A gene (p < 0.05). |
| Bulmer, 1998 | 60 | N/A | N/A | N/A | N/A | Non-endometrial pathology | N/A | N/A | 20 | 40 | 30 | 30 | 30 | INCREASED number in the glandular epithelium in the early secretory compared to the matched eutopic endometrium (p = 0.0002). |
| Ma, 2021 | 6 | 0 | 3 | 1 | 31.7 | Non-endometrial pathology | N/A | 30.4 | 6 | 0 | 3 | 3 | 3 |
INCREASED ratio of naive CD8+ T cells (p < 0.05). DECREASED ratio of effector CD8+ T cells (p < 0.05). |
| Wu, 2019 | 30 | 0 | 15 | N/A | 44.60 ( ± 2.57) | Non-endometrial pathology | N/A | 47.00 ( ± 4.04) | 30 | 0 | 15 | 15 | 15 |
INCREASED CD8+ quantity per mm2 when compared to control endometrium (p < 0.01). NO DIFFERENCE when compared to matched eutopic endometrium (p > 0.01). |
| Zhong, 2021 | 204 | 20 | 62 | N/A | N/A | N/A | N/A | N/A | 204 | 0 | 112 | 24 | 68 |
INCREASED CD8+ T ratio when compared to control endometrium (p = 0.033). NO DIFFERENCE in CD8+ T cell ratio when compared to matched eutopic endometrium. |
N/A, Not available; Age (yrs)*: Mean ± SD or Median (Range).