Table 5.
CD8+ T cell outcomes in peritoneal fluid.
| FIRST AUTHOR, YEAR |
TOTAL (N) | ENDOMETRIOSIS (N) | CONTROLS (N) | UTERINE CYCLE PHASE (N) | ANALYZED SAMPLES OF THE TOTAL (N) | CD8+ T CELL FINDINGS IN ENDOMETRIOSIS VERSUS CONTROLS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stage I/II | Stage III/IV | Subfertility | Age (yrs)* | Diagnosis | Subfertility | Age (yrs)* | Proliferative | Secretory | Endometriosis | Controls | Cell proportion | Activation and cytotoxicity | CD4/CD8 ratio | ||
| Chen, 2017 |
63 | 14 | 18 | N/A | 29 (18–38) |
Non-endometrial pathology | N/A | 32 (19–44) | 63 | 0 | 4 | 4 | NO DIFFERENCE among CD3+ cells. | ||
| D’Hooghe, 1996 | 57 | 20 | 11 | N/A | N/A | Healthy | N/A | N/A | 21 | 18 | 36 | 21 | INCREASED in long-term spontaneous endometriosis when compared with other groups (p = 0.01). | ||
| Deng, 2022 |
49 | 0 | 24 | N/A | 31 (± 6.8) | Non-endometrial pathology | N/A | 40 ( ± 5.6) | 49 | 0 | 15 | 18 |
NO DIFFERENCE among lymphocytes. INCREASED among all peritoneal fluid cells (p = 0.0032). |
NO DIFFERENCE. | |
| Gallinelli, 2004 | 63 | 21 | 22 | 0 | 33.1 ( ± 4.4) | Tubal ligation/reanastomosis | 3 ± 0.6 yrs | 31.7 ( ± 3.7) | 80 | 0 | 0 | 20 | DECREASED concentration of HLA-DR+ subsets (p < 0.02). | DECREASED (p < 0.05). | |
| Ho, 1995 |
29 | 8 | 11 | N/A | N/A | Tubal ligation | 0 | N/A | 29 | 0 | 19 | 10 | NO DIFFERENCE in HLA-DR+, CD25+, CD28+ and CD69+ subsets between mild and severe endometriosis and controls. | ||
| Li, 2019 |
50 | 17 | 15 | N/A | 32.6 ( ± 1.10) | Non-endometrial pathology | N/A | 33.3 ( ± 1.23) | 50 | 0 | 29 | 10 | INCREASED CD8+ MAIT cell subsets (p = 0.0454). | INCREASED expression of CD38 among CD8+ MAIT cells (p = 0.0071). | |
| Mier-Cabrera, 2011 | 62 | 32 | 0 | 32 | 32.7 ( ± 2.5) | Tubal ligation | 0 | 33.8 ( ± 5.4) | 0 | 62 | 32 | 30 | NO DIFFERENCE among lymphocytes. | NO DIFFERENCE in the ratio of IFN-gamma and IL-2 expressing cells. | |
| Opsahl, 1994 | 20 | 8 | 0 | 8 | N/A | Tubal ligation | 0 | N/A | 11 | 9 | 8 | 12 | NO DIFFERENCE among all phases. | NO DIFFERENCE in the ratio of HLA-DR+ subsets. | |
| Zou, 2021 |
2 | 0 | 1 | N/A | 36 | Septate uterus | N/A | 28 | 2 | 0 | 1 | 1 | DECREASED mean gene expression of GNLY, GZMB, GZMH and GZMK (p < 0.0001). | ||
N/A, Not available; Age (yrs)*: Mean ± SD or Median (Range).