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. 2023 Jul 13;9(4):39. doi: 10.3390/ncrna9040039

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA-seq data analysis of DOX-induced senescent PD-L1+ and PD-L1- cells compared to the control cells. (A) Volcano plot of differentially expressed genes derived using the threshold values of 2-fold change and FDR < 0.05. (B) Number of differentially expressed lncRNA, protein-coding, and other types of genes. (C) Venn diagrams of shared up- and down-regulated lncRNA and protein-coding genes between DOX-induced senescent PD-L1+ and PD-L1- cells compared to the control cells (p-value < 0.0001). (D) Top 10 enriched GO terms and (E) KEGG pathways for the shared up-regulated protein-coding genes. (F) Top 10 enriched GO terms and (G) KEGG pathways for the shared down-regulated protein-coding genes.