Table 2.

Comprehensive table to summarize the different modes of delivery.

Mode of mAb Delivery	Advantages	Disadvantages
Adeno-Associated Virus (AAV)	(1)High serum concentrations	(1)Vector immunity (2)Risk of insertional mutagenesis (3)Insert capacity limitation (4)Time to peak expression can take months (5)Expensive and complex manufacturing (6)Cold chain requirement
Deoxyribonucleic Acid (DNA)	(1)Repeatable dosing (2)Easily manufactured and manipulated (3)Stable at room temperature	(1)Delivery oftentimes requires electroporation (2)Time to peak expression can take weeks
Messenger RNA (mRNA)	(1)Repeatable dosing (2)Only a few hours for expression with peak expression within days (3)Cell-free production	(1)LNP toxicity (2)High cost for manufacturing and upscaling (3)Instability during long-term storage (4)Cold chain requirement