Table 3.

Regression modelling results, including slopes, significance levels and E-values for cannabis herb THC concentration–cancer relationship slopes by mixed-effects regression.

Cancer	β-Estimate	Std. Error	p-Value	P. Adj. Holm	E-Value Estimate	E-Value Lower Bound
All Cancers nNMSC	2.6457	0.0778	4.69 × 10−180	1.41 × 10−178	4.88 × 1013	8.28 × 1012
All Cancers	2.8076	0.1071	6.70 × 10−102	1.94 × 10−100	3.15 × 1010	5.46 × 109
Prostate	5.2624	0.2489	1.55 × 10−86	4.35 × 10−85	4.59 × 107	9.56 × 106
Breast	2.4686	0.1369	1.36 × 10−65	3.67 × 10−64	3.51 × 106	7.37 × 105
Melanoma	5.9745	0.3598	8.89 × 10−57	2.31 × 10−55	5.59 × 105	1.28 × 105
Kidney	3.5398	0.2357	1.64 × 10−47	4.11 × 10−46	3.32 × 105	6.95 × 104
Colorectum	2.5415	0.1742	4.61 × 10−45	1.11 × 10−43	2.03 × 105	4.33 × 104
Pancreas	3.6625	0.2554	1.04 × 10−43	2.40 × 10−42	1.67 × 105	3.55 × 104
Testis	4.5855	0.3263	2.84 × 10−41	6.25 × 10−40	5.74 × 107	5.26 × 106
Thyroid	4.9267	0.3666	3.26 × 10−38	6.85 × 10−37	8.56 × 107	6.63 × 106
Non-Hodgkin’s Lymphoma	3.7844	0.2854	7.36 × 10−38	1.47 × 10−36	6.82 × 104	1.46 × 104
Lung	2.0357	0.1687	5.35 × 10−32	1.02 × 10−30	3.40 × 104	7.01 × 103
Anus	3.6672	0.3097	1.61 × 10−30	2.89 × 10−29	2.77 × 106	2.68 × 105
Oesophagus	3.5244	0.3847	1.71 × 10−19	2.90 × 10−18	2.58 × 103	557.87
Leukaemia—Myeloid	4.2458	0.6638	8.92 × 10−10	1.43 × 10−8	2.22 × 105	6.35 × 103
Oropharynx_Broad	2.5577	0.4523	2.82 × 10−8	4.23 × 10−7	5.05 × 102	74.07
Leukaemia—Lymphoid	1.6165	0.4299	2.16 × 10−4	0.0026	1784.06	51.56
Brain	1.1480	0.3174	3.09 × 10−4	0.0034	19.93	5.26
Myeloma	0.8656	0.2619	9.80 × 10−4	0.0098	127.86	10.41
Corpus Uteri	1.2936	0.4601	0.0050	0.0400	16.44	3.24
Liver	0.7809	0.3581	0.0294	0.2059	37.76	2.05
Hodgkin’s	0.4718	0.3032	0.1200	0.5999	12.08	1.00
Cervix	0.1742	0.3411	0.6097	1.0000	2.38	1.00
Bladder	0.0250	0.2849	0.9302	1.0000	1.35	1.00
Kaposi	0.0346	0.4840	0.9432	1.0000	2.09	1.00
Ovary	−0.0127	0.3205	0.9684	1.0000	1.21	-
Oropharynx	−2.7034	1.4854	0.0699	0.4192	54.33	-
Gallbladder and Biliary	−1.1202	0.3420	0.0011	0.0098	487.89	-
Larynx	−1.3647	0.3578	1.42 × 10−4	0.0018	27.57	-
Stomach	−0.8809	0.2164	4.92 × 10−5	6.89 × 10−4	53.25	-

Table key: β-Estimate—estimate of the regression coefficient; Std. Error—standard error of the regression coefficient; p-value—significance level; P. Adj. Holm—p-value adjusted for multiple testing by the method of Holm; E-value—expected value required of some unknown confounder covariate with both the exposure and the outcome to explain the observed effect; lower bound of the E-value—the 95% lower bound of the confidence interval of the E-value.