Table 4.
Regression modelling results, including slopes, significance levels and E-values for THC concentration of cannabis resin–cancer relationship slopes by mixed-effects regression.
| Cancer | β-Estimate | Std. Error | p-Value | P. Adj. Holm | E-Value Estimate | E-Value Lower Bound |
|---|---|---|---|---|---|---|
| All Cancers nNMSC | 1.1789 | 0.0622 | 2.82 × 10−70 | 8.46 × 10−69 | 2.22 × 105 | 6.70 × 104 |
| Melanoma | 2.8370 | 0.2030 | 1.36 × 10−41 | 3.93 × 10−40 | 795.41 | 343.77 |
| All Cancers | 1.0317 | 0.0758 | 7.34 × 10−37 | 2.05 × 10−35 | 2065.96 | 761.63 |
| Pancreas | 1.5037 | 0.1432 | 6.91 × 10−25 | 1.80 × 10−23 | 185.22 | 79.36 |
| Breast | 0.7634 | 0.0813 | 2.34 × 10−20 | 5.86 × 10−19 | 142.23 | 58.19 |
| Anus | 1.1325 | 0.1299 | 1.12 × 10−17 | 2.69 × 10−16 | 159.29 | 59.29 |
| Non-Hodgkin’s Lymphoma | 1.4279 | 0.1679 | 4.80 × 10−17 | 1.10 × 10−15 | 101.29 | 40.73 |
| Lung | 0.7312 | 0.0921 | 4.22 × 10−15 | 9.29 × 10−14 | 71.04 | 29.12 |
| Kidney | 0.9545 | 0.1363 | 3.85 × 10−12 | 8.08 × 10−11 | 41.16 | 17.33 |
| Oesophagus | 1.2442 | 0.2143 | 7.86 × 10−9 | 1.42 × 10−7 | 23.50 | 9.87 |
| Testis | 0.8143 | 0.1502 | 7.38 × 10−8 | 1.26 × 10−6 | 33.71 | 11.76 |
| Oropharynx | 2.3818 | 0.5030 | 3.70 × 10−6 | 5.92 × 10−5 | 69.39 | 15.59 |
| Oropharynx_Broad | 1.1861 | 0.2844 | 3.67 × 10−5 | 4.78 × 10−4 | 24.73 | 7.15 |
| Bladder | 0.5357 | 0.1597 | 8.18-04 | 0.0098 | 7.87 | 3.04 |
| Hodgkin’s | 0.3397 | 0.1236 | 0.0061 | 0.0608 | 6.91 | 2.28 |
| Brain | 0.5346 | 0.1948 | 0.0061 | 0.0608 | 5.20 | 2.05 |
| Thyroid | 0.3513 | 0.1603 | 0.0287 | 0.2006 | 5.58 | 1.51 |
| Prostate | 0.3118 | 0.1532 | 0.0420 | 0.2521 | 4.40 | 1.23 |
| Kaposi | 0.1992 | 0.5144 | 0.6998 | 1.0000 | 9.45 | 1.00 |
| Myeloma | 0.0387 | 0.1039 | 0.7096 | 1.0000 | 1.70 | 1.00 |
| Colorectum | 0.0315 | 0.0960 | 0.7429 | 1.0000 | 1.58 | 1.00 |
| Corpus Uteri | −0.3324 | 0.2662 | 0.2119 | 0.8477 | 2.82 | - |
| Leukaemia—Myeloid | −0.4144 | 0.2523 | 0.1020 | 0.5100 | 5.73 | - |
| Liver | −0.3425 | 0.1377 | 0.0130 | 0.1044 | 7.02 | - |
| Leukaemia—Lymphoid | −0.4516 | 0.1521 | 0.0033 | 0.0366 | 15.46 | - |
| Cervix | −0.8035 | 0.1902 | 2.54 × 10−5 | 3.56 × 10−4 | 12.79 | - |
| Ovary | −0.8408 | 0.1827 | 4.57 × 10−6 | 6.86 × 10−5 | 14.58 | - |
| Gallbladder and Biliary | −0.8315 | 0.1407 | 4.78 × 10−9 | 9.08 × 10−8 | 116.77 | - |
| Larynx | −1.2162 | 0.2026 | 2.47 × 10−9 | 4.94 × 10−8 | 21.12 | - |
| Stomach | −1.3226 | 0.1114 | 4.89 × 10−31 | 1.32 × 10−29 | 352.51 | - |
Table key: β-Estimate—estimate of the regression coefficient; Std. Error—standard error of the regression coefficient; p-value—significance level; P. Adj. Holm—p-value adjusted for multiple testing by the method of Holm; E-value—expected value required of some unknown confounder covariate with both the exposure and the outcome to explain the observed effect; lower bound of the E-value—the 95% lower bound of the confidence interval of the E-value.