Table 8.
Positive and significant terms from the additive panel model.
| Cancer | Term | β-Estimate | Std. Error | p-Value | Adj. P. FDR | Adj. P. Holm | E-Value Estimate | E-Value 95% Lower Bound |
|---|---|---|---|---|---|---|---|---|
| All Cancers nNMSC | LM.Cannabis | 28.793 | 2.305 | 7.96 × 10−26 | 5.58 × 10−25 | 4.86 × 10−24 | 3.50 × 1060 | 1.29 × 1051 |
| Myeloma | LM.Cannabis | 18.834 | 2.110 | 1.64 × 10−16 | 7.15 × 10−16 | 8.99 × 10−15 | 1.79 × 1043 | 6.91 × 1033 |
| Lung | LM.Cannabis | 27.039 | 2.293 | 1.32 × 10−25 | 8.38 × 10−25 | 7.90 × 10−24 | 7.26 × 1039 | 2.00 × 1033 |
| Kidney | LM.Cannabis | 34.251 | 2.951 | 4.67 × 10−25 | 2.73 × 10−24 | 2.76 × 10−23 | 1.70 × 1039 | 4.68 × 1032 |
| Pancreas | LM.Cannabis | 29.502 | 2.956 | 7.13 × 10−20 | 3.57 × 10−19 | 4.07 × 10−18 | 5.97 × 1033 | 1.65 × 1027 |
| Leukaemia—Lymphoid | LM.Cannabis | 9.998 | 2.584 | 3.66 × 10−4 | 5.56 × 10−4 | 9.14 × 10−3 | 1.09 × 1045 | 2.64 × 1022 |
| All Cancers nNMSC | THC.Herb | 10.642 | 0.521 | 1.15 × 10−47 | 1.34 × 10−46 | 7.48 × 10−46 | 3.69 × 1022 | 2.73 × 1020 |
| Non-Hodgkin’s Lymphoma | LM.Cannabis | 26.819 | 3.429 | 1.75 × 10−13 | 6.45 × 10−13 | 9.10 × 10−12 | 3.42 × 1026 | 9.39 × 1019 |
| Colorectum | LM.Cannabis | 18.142 | 2.303 | 1.13 × 10−13 | 4.38 × 10−13 | 5.97 × 10−12 | 5.83 × 1025 | 2.76 × 1019 |
| Prostate | LM.Cannabis | 22.525 | 3.112 | 6.20 × 10−12 | 1.97 × 10−11 | 3.04 × 10−10 | 3.77 × 1024 | 1.04 × 1018 |
| All Cancers | LM.Cannabis | 17.153 | 4.312 | 1.51 × 10−4 | 2.40 × 10−4 | 4.07 × 10−3 | 4.43 × 1034 | 5.71 × 1017 |
| Pancreas | THC.Herb | 15.302 | 0.584 | 1.27 × 10−72 | 8.88 × 10−71 | 8.88 × 10−71 | 4.61 × 1017 | 2.33 × 1016 |
| Hodgkin’s | LM.Cannabis | 13.231 | 2.507 | 2.91 × 10−7 | 6.56 × 10−7 | 1.16 × 10−5 | 3.05 × 1025 | 1.41 × 1016 |
| Stomach | LM.Cannabis | 20.239 | 3.032 | 1.67 × 10−10 | 4.88 × 10−10 | 7.87 × 10−9 | 4.86 × 1022 | 1.34 × 1016 |
| Stomach | THC.Herb | 15.302 | 0.599 | 1.20 × 10−70 | 4.21 × 10−69 | 8.29 × 10−69 | 1.68 × 1017 | 8.51 × 1015 |
| Prostate | THC.Herb | 15.119 | 0.616 | 2.58 × 10−67 | 6.01 × 10−66 | 1.75 × 10−65 | 3.94 × 1016 | 1.98 × 1015 |
| Breast | LM.Cannabis | 13.958 | 2.225 | 1.66 × 10−9 | 4.29 × 10−9 | 7.28 × 10−8 | 2.18 × 1021 | 5.99 × 1014 |
| Kidney | THC.Herb | 13.038 | 0.583 | 8.04 × 10−61 | 1.41 × 10−59 | 5.38 × 10−59 | 1.32 × 1015 | 6.66 × 1013 |
| Lung | THC.Herb | 9.751 | 0.453 | 8.43 × 10−58 | 1.18 × 10−56 | 5.56 × 10−56 | 3.69 × 1014 | 1.86 × 1013 |
| All Cancers | THC.Herb | 9.102 | 1.851 | 4.52 × 10−6 | 8.78 × 10−6 | 1.58 × 10−4 | 3.37 × 1018 | 1.89 × 1011 |
| Breast | THC.Herb | 7.398 | 0.440 | 2.23 × 10−42 | 2.23 × 10−41 | 1.43 × 10−40 | 2.83 × 1011 | 1.43 × 1010 |
| Melanoma | LM.Cannabis | 19.128 | 4.101 | 5.13 × 10−6 | 9.71 × 10−6 | 1.74 × 10−4 | 8.80 × 1015 | 2.42 × 109 |
| Non-Hodgkin’s Lymphoma | THC.Herb | 10.009 | 0.679 | 2.68 × 10−35 | 2.35 × 10−34 | 1.69 × 10−33 | 1.24 × 1010 | 6.20 × 108 |
| Oropharynx | THC.Herb | 17.962 | 5.844 | 3.42 × 10−3 | 4.35 × 10−3 | 5.47 × 10−2 | 4.75 × 1019 | 2.22 × 107 |
| Corpus Uteri | THC.Herb | 10.573 | 0.871 | 7.86 × 10−27 | 6.12 × 10−26 | 4.88 × 10−25 | 2.06 × 108 | 1.06 × 107 |
| Cervix | THC.Herb | 7.048 | 0.692 | 1.79 × 10−20 | 9.64 × 10−20 | 1.04 × 10−18 | 1.15 × 107 | 5.77 × 105 |
| Oropharynx | THC.Resin | 7.056 | 1.081 | 3.30 × 10−8 | 7.96 × 10−8 | 1.38 × 10−6 | 8.17 × 107 | 4.28 × 105 |
| Colorectum | THC.Herb | 4.636 | 0.467 | 1.03 × 10−19 | 4.79 × 10−19 | 5.75 × 10−18 | 6.43 × 106 | 3.36 × 105 |
| Myeloma | THC.Herb | 4.293 | 1.067 | 7.80 × 10−5 | 1.33 × 10−4 | 2.34 × 10−3 | 1.24 × 1010 | 2.16 × 105 |
| Bladder | LM.Cannabis | 12.723 | 3.734 | 7.68 × 10−4 | 1.12 × 10−3 | 1.77 × 10−2 | 5.35 × 1011 | 1.47 × 105 |
| Larynx | LM.Cannabis | 21.062 | 6.232 | 8.46 × 10−4 | 1.21 × 10−3 | 1.86 × 10−2 | 4.31 × 1011 | 1.19 × 105 |
| Oesophagus | LM.Cannabis | 21.862 | 6.703 | 1.27 × 10−3 | 1.74 × 10−3 | 2.53 × 10−2 | 1.73 × 1011 | 4.78 × 104 |
| Ovary | THC.Herb | 6.596 | 0.867 | 6.26 × 10−13 | 2.09 × 10−12 | 3.13 × 10−11 | 2.24 × 105 | 1.13 × 104 |
| Larynx | THC.Herb | 8.671 | 1.231 | 1.95 × 10−11 | 5.93 × 10−11 | 9.35 × 10−10 | 9.27 × 104 | 4.69 × 103 |
| Liver | THC.Herb | 6.224 | 1.927 | 1.44 × 10−3 | 1.94 × 10−3 | 2.74 × 10−2 | 1.64 × 108 | 2.64 × 103 |
| Melanoma | THC.Herb | 5.221 | 0.810 | 6.37 × 10−10 | 1.72 × 10−9 | 2.87 × 10−8 | 3.72 × 104 | 1.88 × 103 |
| Oropharynx | Income | 2.004 | 0.345 | 4.46 × 10−7 | 9.75 × 10−7 | 1.74 × 10−5 | 2.90 × 102 | 53.68 |
| Bladder | THC.Herb | 2.976 | 0.738 | 7.35 × 10−5 | 1.29 × 10−4 | 2.28 × 10−3 | 9.41 × 102 | 47.12 |
| Liver | LM.Cannabis | 8.543 | 3.824 | 2.66 × 10−2 | 2.86 × 10−2 | 0.1792 | 1.45 × 1011 | 44.49 |
| Oesophagus | THC.Herb | 5.217 | 1.324 | 1.07 × 10−4 | 1.74 × 10−4 | 0.0031 | 814.30 | 40.70 |
| Testis | Income | 0.568 | 0.090 | 1.72 × 10−9 | 4.30 × 10−9 | 7.40 × 10−8 | 18.99 | 9.07 |
| Brain | THC.Herb | 3.806 | 1.278 | 3.20 × 10−3 | 4.14 × 10−3 | 0.0543 | 188.66 | 9.00 |
| Gallbladder and Biliary | Income | 0.600 | 0.123 | 2.23 × 10−6 | 4.59 × 10−6 | 8.24 × 10−5 | 23.49 | 8.33 |
| Thyroid | THC.Resin | 1.567 | 0.533 | 3.62 × 10−3 | 4.52 × 10−3 | 0.0547 | 61.00 | 5.75 |
| Anus | Income | 0.347 | 0.069 | 1.09 × 10−6 | 2.30 × 10−6 | 4.12 × 10−5 | 11.84 | 5.52 |
| Myeloma | THC.Resin | 0.632 | 0.222 | 4.79 × 10−3 | 5.68 × 10−3 | 0.0575 | 54.80 | 5.11 |
| Gallbladder and Biliary | Alcohol | 0.296 | 0.037 | 1.09 × 10−13 | 4.38 × 10−13 | 5.87 × 10−12 | 6.27 | 4.48 |
| Ovary | LM.Cannabis | 9.010 | 4.381 | 4.08 × 10−2 | 4.14 × 10−2 | 0.1792 | 1.58 × 107 | 3.76 |
| Myeloma | Income | 0.272 | 0.069 | 1.06 × 10−4 | 1.74 × 10−4 | 0.0031 | 7.82 | 3.53 |
| Oropharynx | Tobacco | 0.298 | 0.037 | 1.99 × 10−10 | 5.58 × 10−10 | 9.17 × 10−9 | 3.61 | 2.89 |
| All Cancers nNMSC | THC.Resin | 0.643 | 0.290 | 2.78 × 10−2 | 2.95 × 10−2 | 0.1792 | 43.75 | 2.24 |
| Leukaemia—Myeloid | Alcohol | 0.164 | 0.062 | 1.15 × 10−2 | 1.32 × 10−2 | 0.1155 | 5.24 | 1.96 |
| Testis | Alcohol | 0.126 | 0.035 | 3.89 × 10−4 | 5.80 × 10−4 | 0.0093 | 2.70 | 1.83 |
| Hodgkin’s | THC.Resin | 0.564 | 0.263 | 3.29 × 10−2 | 3.38 × 10−2 | 0.1792 | 23.15 | 1.80 |
| Prostate | Tobacco | 0.089 | 0.011 | 2.47 × 10−13 | 8.66 × 10−13 | 1.26 × 10−11 | 1.80 | 1.64 |
| Corpus Uteri | Tobacco | 0.085 | 0.016 | 1.05 × 10−7 | 2.45 × 10−7 | 4.31 × 10−6 | 1.59 | 1.43 |
| Breast | Income | 0.145 | 0.060 | 0.0172 | 0.0192 | 0.1379 | 2.69 | 1.42 |
| Myeloma | Tobacco | 0.029 | 0.006 | 2.86 × 10−6 | 5.72 × 10−6 | 1.03 × 10−4 | 1.60 | 1.42 |
| Anus | Alcohol | 0.066 | 0.027 | 0.0140 | 0.0158 | 0.1263 | 2.18 | 1.36 |
| Breast | Tobacco | 0.037 | 0.008 | 1.21 × 10−5 | 2.24 × 10−5 | 4.01 × 10−4 | 1.53 | 1.36 |
| Hodgkin’s | Income | 0.176 | 0.082 | 0.0325 | 0.0338 | 0.1792 | 3.75 | 1.35 |
| Kidney | Tobacco | 0.045 | 0.011 | 4.32 × 10−5 | 7.75 × 10−5 | 0.0014 | 1.50 | 1.32 |
| Lung | Tobacco | 0.032 | 0.008 | 0.0002 | 0.0003 | 0.0046 | 1.47 | 1.29 |
| Hodgkin’s | Tobacco | 0.023 | 0.007 | 0.0011 | 0.0016 | 0.0237 | 1.45 | 1.25 |
| Non-Hodgkin’s Lymphoma | Tobacco | 0.041 | 0.013 | 0.0016 | 0.0022 | 0.0294 | 1.42 | 1.23 |
| Pancreas | Tobacco | 0.031 | 0.011 | 0.0039 | 0.0048 | 0.0551 | 1.39 | 1.19 |
| Colorectum | Tobacco | 0.025 | 0.009 | 0.0041 | 0.0050 | 0.0551 | 1.39 | 1.19 |
| All Cancers | Tobacco | 0.039 | 0.017 | 0.0256 | 0.0280 | 0.1792 | 1.68 | 1.19 |
| Stomach | Tobacco | 0.030 | 0.011 | 0.0077 | 0.0089 | 0.0842 | 1.37 | 1.17 |
| Ovary | Tobacco | 0.033 | 0.016 | 0.0418 | 0.0418 | 0.1792 | 1.31 | 1.05 |
Table key: β-Estimate—estimate of the regression coefficient; Std. Error—standard error of the regression coefficient; p-value—significance level; P. Adj. Holm—p-value adjusted for multiple testing by the method of Holm; Adj. P. FDR—p-value adjusted for multiple testing by the false discovery rate method of Benjamini and Hochberg; E-value—expected value required of some unknown confounder covariate with both the exposure and the outcome to explain the observed effect; lower bound of the E-value—the 95% lower bound of the confidence interval of the E-value.