Table 10.
Significant positive terms from interactive panel regression.
| Cancer | Term | β-Estimate | Std. Error | p-Value | Adj. P. FDR | Adj. P. Holm | E-Value Estimate | E-Value 95% Lower Bound |
|---|---|---|---|---|---|---|---|---|
| Colorectum | Herb. THC | 55.387 | 5.081 | 1.17 × 10−26 | 1.13 × 10−25 | 3.14 × 10−24 | 8.51 × 1030 | 2.72 × 1025 |
| Breast | Herb. THC | 37.005 | 3.771 | 4.69 × 10−22 | 3.59 × 10−21 | 1.22 × 10−19 | 7.65 × 1027 | 2.43 × 1022 |
| Gallbladder and Biliary | Herb. THC | 20.744 | 2.892 | 1.41 × 10−12 | 6.28 × 10−12 | 3.28 × 10−10 | 1.84 × 1026 | 1.53 × 1019 |
| Oropharynx_Broad | Herb. THC | 23.856 | 4.274 | 4.15 × 108 | 1.24 × 10−7 | 8.26 × 10−6 | 1.31 × 1026 | 1.17 × 1017 |
| All Cancers | Herb. THC | 12.034 | 2.019 | 4.45 × 109 | 1.46 × 10−8 | 9.26 × 10−7 | 1.41 × 1023 | 4.48 × 1015 |
| Thyroid | Herb. THC | 20.386 | 3.101 | 7.61 × 10−11 | 2.80 × 10−10 | 1.67 × 10−8 | 2.72 × 1021 | 1.40 × 1015 |
| Anus | Herb. THC | 13.789 | 2.229 | 8.74 × 10−10 | 3.03 × 10−9 | 1.86 × 10−7 | 1.74 × 1020 | 8.63 × 1013 |
| Testis | Herb. THC | 33.843 | 6.241 | 7.22 × 108 | 2.03 × 10−7 | 1.39 × 10−5 | 5.43 × 1017 | 2.80 × 1011 |
| Stomach | Herb. THC | 24.735 | 4.252 | 7.31 × 109 | 2.28 × 10−8 | 1.49 × 10−6 | 4.63 × 1016 | 1.46 × 1011 |
| Oropharynx | Resin. THC | 7.349 | 0.625 | 4.34 × 10−22 | 3.40 × 10−21 | 1.13 × 10−19 | 1.92 × 1011 | 2.86 × 109 |
| Corpus Uteri | Herb. THC | 25.436 | 5.293 | 1.70 × 106 | 4.16 × 10−6 | 3.01 × 10−4 | 6.37 × 1013 | 2.03 × 108 |
| Prostate | Herb. THC | 24.791 | 5.498 | 7.03 × 106 | 1.65 × 10−5 | 1.21 × 10−3 | 9.35 × 1012 | 2.98 × 107 |
| Oesophagus | Herb. THC | 13.982 | 3.228 | 1.58 × 105 | 3.58 × 10−5 | 2.65 × 10−3 | 3.05 × 1012 | 9.59 × 106 |
| Leukaemia—Lymphoid | LM. Cannabis: Herb. THC | 7.397 | 3.030 | 1.57 × 102 | 2.59 × 10−2 | 1.0000 | 2.60 × 1023 | 7.91 × 104 |
| Melanoma | Herb. THC | 10.965 | 3.151 | 5.17 × 104 | 1.03 × 10−3 | 7.76 × 10−2 | 1.26 × 1010 | 3.90 × 104 |
| Cervix | Herb. THC | 13.081 | 5.359 | 1.48 × 102 | 2.46 × 10−2 | 1.00 | 1.47 × 107 | 45.71 |
| Oesophagus | Resin. THC | 1.763 | 0.155 | 1.11 × 10−28 | 1.27 × 10−27 | 3.04 × 10−26 | 68.18 | 36.84 |
| All Cancers nNMSC | Tobacco: Herb. THC | 0.527 | 0.059 | 9.85 × 10−19 | 5.87 × 10−18 | 2.45 × 10−16 | 48.59 | 23.92 |
| Oropharynx | Income | 1.024 | 0.191 | 3.81 × 10−7 | 1.01 × 10−6 | 7.12 × 105 | 67.24 | 18.20 |
| Stomach | LM. Cannabis | 1.283 | 0.096 | 3.16 × 10−38 | 6.28 × 10−37 | 8.98 × 10−36 | 13.60 | 10.06 |
| Kidney | Herb. THC | 6.010 | 2.758 | 2.95 × 10−2 | 4.60 × 10−2 | 1.00 | 2.69 × 106 | 7.94 |
| Colorectum | LM. Cannabis | 1.323 | 0.115 | 2.41 × 10−29 | 3.27 × 10−28 | 6.69 × 10−27 | 10.26 | 7.56 |
| Myeloma | Resin. THC | 0.526 | 0.090 | 6.60 × 10−9 | 2.12 × 10−8 | 1.36 × 10−6 | 14.34 | 7.06 |
| Ovary | Herb. THC | 9.381 | 4.345 | 3.10 × 10−2 | 4.76 × 10−2 | 1.00 | 2.37 × 106 | 6.91 |
| Larynx | Resin. THC | 0.796 | 0.145 | 4.56 × 10−8 | 1.33 × 10−7 | 8.99 × 10−6 | 10.56 | 5.48 |
| Larynx | LM. Cannabis | 0.612 | 0.068 | 8.34 × 10−19 | 5.08 × 10−18 | 2.09 × 10−16 | 6.93 | 5.05 |
| Leukaemia—Lymphoid | Alcohol | 0.164 | 0.021 | 4.81 × 10−13 | 2.24 × 10−12 | 1.13 × 10−10 | 5.96 | 4.29 |
| Breast | LM. Cannabis | 0.628 | 0.086 | 3.61 × 10−13 | 1.71 × 10−12 | 8.51 × 10−11 | 5.32 | 3.83 |
| Thyroid | LM. Cannabis | 0.433 | 0.065 | 4.51 × 10−11 | 1.75 × 10−10 | 1.00 × 10−8 | 5.07 | 3.57 |
| Pancreas | Herb. THC | 5.546 | 2.709 | 4.09 × 10−2 | 6.06 × 10−2 | 1.00 | 1.14 × 106 | 3.00 |
| Hodgkin’s | LM. Cannabis | 0.253 | 0.044 | 1.54 × 10−8 | 4.64 × 10−8 | 3.08 × 10−6 | 4.28 | 2.98 |
| Gallbladder and Biliary | Tobacco: LM. Cannabis: Herb. THC | 0.266 | 0.034 | 7.85 × 10−15 | 4.10 × 10−14 | 1.90 × 10−12 | 3.72 | 2.95 |
| Leukaemia—Myeloid | LM. Cannabis: Herb. THC | 10.783 | 5.449 | 4.96 × 10−2 | 7.24 × 10−2 | 1.00 | 1.08 × 1019 | 2.67 |
| Oropharynx | Tobacco: Herb. THC | 0.509 | 0.187 | 7.31 × 10−3 | 1.27 × 10−2 | 9.36 × 10−1 | 11.00 | 2.66 |
| Leukaemia—Myeloid | Alcohol | 0.195 | 0.037 | 6.00 × 10−7 | 1.53 × 10−6 | 1.09 × 10−4 | 3.78 | 2.63 |
| Corpus Uteri | LM. Cannabis | 0.611 | 0.120 | 3.94 × 10−7 | 1.04 × 10−6 | 7.34 × 10−5 | 3.64 | 2.55 |
| Gallbladder and Biliary | LM. Cannabis | 0.252 | 0.055 | 5.50 × 10−6 | 1.31 × 10−5 | 9.57 × 104 | 3.55 | 2.40 |
| Colorectum | Tobacco: LM. Cannabis: Herb. THC | 0.453 | 0.069 | 5.71 × 10−11 | 2.18 × 10−10 | 1.26 × 10−8 | 2.96 | 2.37 |
| Myeloma | Income | 0.137 | 0.023 | 6.68 × 10−9 | 2.12 × 10−8 | 1.37 × 10−6 | 2.77 | 2.19 |
| Testis | Income | 0.440 | 0.076 | 7.35 × 10−9 | 2.28 × 10−8 | 1.49 × 10−6 | 2.76 | 2.18 |
| Prostate | LM. Cannabis | 0.512 | 0.125 | 4.20 × 10−5 | 9.14 × 10−5 | 6.81 × 10−3 | 3.05 | 2.08 |
| Prostate | Income | 0.372 | 0.054 | 9.01 × 10−12 | 3.63 × 10−11 | 2.03 × 10−9 | 2.47 | 2.08 |
| Stomach | Tobacco: LM. Cannabis: Herb. THC | 0.317 | 0.058 | 4.27 × 10−8 | 1.26 × 10−7 | 8.46 × 10−6 | 2.63 | 2.07 |
| Thyroid | Tobacco: LM. Cannabis: Herb. THC | 0.202 | 0.038 | 9.80 × 10−8 | 2.73 × 10−7 | 1.88 × 10−5 | 2.62 | 2.06 |
| All Cancers | Alcohol | 0.092 | 0.013 | 5.34 × 10−13 | 2.45 × 10−12 | 1.25 × 10−10 | 2.36 | 2.03 |
| Oropharynx | Tobacco | 0.148 | 0.033 | 1.44 × 10−5 | 3.27 × 10−5 | 2.42 × 10−3 | 2.71 | 2.00 |
| Breast | Tobacco: LM. Cannabis: Herb. THC | 0.267 | 0.051 | 1.98 × 10−7 | 5.47 × 10−7 | 3.78 × 10−5 | 2.54 | 2.00 |
| Anus | Tobacco: LM. Cannabis: Herb. THC | 0.138 | 0.027 | 4.91 × 10−7 | 1.26 × 10−6 | 8.99 × 10−5 | 2.55 | 1.98 |
| Breast | Income | 0.216 | 0.037 | 8.22 × 10−9 | 2.53 × 10−8 | 1.66 × 10−6 | 2.25 | 1.87 |
| Non-Hodgkin’s Lymphoma | Tobacco: Herb. THC | 0.314 | 0.103 | 2.26 × 10−3 | 4.19 × 10−3 | 3.12 × 10−1 | 3.15 | 1.82 |
| Lung | Tobacco: Herb. THC | 0.186 | 0.061 | 2.51 × 10−3 | 4.62 × 10−3 | 3.44 × 10−1 | 3.11 | 1.80 |
| Brain | Income | 0.136 | 0.027 | 7.04 × 10−7 | 1.76 × 10−6 | 1.27 × 10−4 | 2.09 | 1.72 |
| Gallbladder and Biliary | Tobacco | 0.072 | 0.005 | 1.16 × 10−41 | 2.89 × 10−40 | 3.34 × 10−39 | 1.76 | 1.68 |
| Larynx | Alcohol | 0.097 | 0.010 | 8.57 × 10−22 | 6.38 × 10−21 | 2.22 × 10−19 | 1.76 | 1.64 |
| Colorectum | Resin. THC | 0.604 | 0.242 | 1.28 × 10−2 | 2.14 × 10−2 | 1.00 | 3.74 | 1.64 |
| Prostate | Tobacco: LM. Cannabis: Herb. THC | 0.253 | 0.074 | 6.94 × 10−4 | 1.37 × 10−3 | 1.03 × 10−1 | 2.03 | 1.53 |
| Kidney | Tobacco: LM. Cannabis: Herb. THC | 0.127 | 0.037 | 7.28 × 10−4 | 1.43 × 10−3 | 1.07 × 10−1 | 2.03 | 1.52 |
| Colorectum | Tobacco | 0.104 | 0.007 | 1.16 × 10−-46 | 4.95 × 10−45 | 3.39 × 10−44 | 1.54 | 1.49 |
| Breast | Tobacco | 0.074 | 0.005 | 5.07 × 10−43 | 1.51 × 10−41 | 1.47 × 10−40 | 1.53 | 1.47 |
| Oesophagus | Tobacco: LM. Cannabis: Herb. THC | 0.136 | 0.044 | 1.86 × 10−3 | 3.48 × 10−3 | 2.60 × 10−1 | 1.96 | 1.45 |
| Stomach | Tobacco | 0.076 | 0.006 | 3.92 × 10−37 | 6.88 × 10−36 | 1.11 × 10−34 | 1.50 | 1.44 |
| Colorectum | Alcohol | 0.103 | 0.017 | 7.58 × 10−10 | 2.66 × 10−9 | 1.62 × 10−7 | 1.54 | 1.41 |
| Pancreas | Tobacco: LM. Cannabis: Herb. THC | 0.108 | 0.037 | 3.44 × 10−3 | 6.22 × 10−3 | 4.62 × 10−1 | 1.91 | 1.40 |
| Ovary | LM. Cannabis | 0.249 | 0.099 | 1.16 × 10−2 | 1.97 × 10−2 | 1.00 | 2.26 | 1.40 |
| Corpus Uteri | Tobacco | 0.077 | 0.007 | 1.75 × 10−25 | 1.58 × 10−24 | 4.66 × 10−23 | 1.43 | 1.37 |
| Oropharynx | Tobacco: LM. Cannabis | 0.060 | 0.020 | 2.75 × 10−3 | 5.02 × 10−3 | 3.74 × 10−1 | 1.76 | 1.37 |
| All Cancers nNMSC | Tobacco: LM. Cannabis | 0.014 | 0.001 | 1.10 × 10−28 | 1.27 × 10−27 | 3.01 × 10−26 | 1.41 | 1.36 |
| Ovary | Tobacco | 0.056 | 0.006 | 3.11 × 10−20 | 2.21 × 10−19 | 8.00 × 10−18 | 1.39 | 1.34 |
| Prostate | Tobacco | 0.068 | 0.008 | 7.41 × 10−19 | 4.60 × 10−18 | 1.86 × 10−16 | 1.38 | 1.33 |
| Corpus Uteri | Tobacco: LM. Cannabis: Herb. THC | 0.188 | 0.072 | 0.0085 | 0.0147 | 1.0000 | 1.83 | 1.32 |
| Hodgkin’s | Tobacco: LM. Cannabis: Herb. THC | 0.067 | 0.026 | 0.0091 | 0.0157 | 1.0000 | 1.84 | 1.31 |
| Bladder | Resin. THC | 0.266 | 0.125 | 0.0330 | 0.0505 | 1.0000 | 3.30 | 1.30 |
| Testis | Tobacco | 0.063 | 0.009 | 2.70 × 10−11 | 1.06 × 10−10 | 6.02 × 10−9 | 1.37 | 1.29 |
| Prostate | Alcohol | 0.075 | 0.018 | 3.02 × 10−5 | 6.71 × 10−5 | 0.0050 | 1.41 | 1.27 |
| Oesophagus | Alcohol | 0.041 | 0.011 | 1.26 × 10−4 | 2.63 × 10−4 | 0.0198 | 1.39 | 1.25 |
| Stomach | Alcohol | 0.053 | 0.014 | 1.41 × 10−4 | 2.92 × 10−4 | 0.0219 | 1.39 | 1.25 |
| Oropharynx_Broad | Tobacco | 0.037 | 0.012 | 0.0017 | 0.0033 | 0.2432 | 1.42 | 1.23 |
| Larynx | Tobacco | 0.024 | 0.004 | 9.70 × 10−9 | 2.95 × 10−8 | 1.95 × 10−6 | 1.29 | 1.22 |
| Melanoma | Tobacco: LM. Cannabis | 0.020 | 0.002 | 4.91 × 10−18 | 2.87 × 10−17 | 1.22 × 10−15 | 1.25 | 1.22 |
| Liver | Tobacco: LM. Cannabis | 0.018 | 0.002 | 3.69 × 10−16 | 2.03 × 10−15 | 9.03 × 10−14 | 1.25 | 1.21 |
| Cervix | Alcohol | 0.059 | 0.018 | 0.0008 | 0.0016 | 0.1181 | 1.36 | 1.21 |
| Breast | Alcohol | 0.041 | 0.012 | 0.0011 | 0.0020 | 0.1510 | 1.35 | 1.20 |
| Lung | Tobacco: LM. Cannabis | 0.011 | 0.001 | 5.55 × 10−15 | 2.95 × 10−14 | 1.35 × 10−12 | 1.23 | 1.20 |
| Melanoma | Income | 0.073 | 0.031 | 0.0183 | 0.0297 | 1.0000 | 1.60 | 1.19 |
| Bladder | LM. Cannabis | 0.126 | 0.059 | 0.0332 | 0.0505 | 1.0000 | 2.08 | 1.19 |
| Pancreas | Tobacco: LM. Cannabis | 0.014 | 0.002 | 1.62 × 10−12 | 7.01 × 10−12 | 3.73 × 10−10 | 1.22 | 1.18 |
| Melanoma | Tobacco: LM. Cannabis: Herb. THC | 0.095 | 0.043 | 0.0266 | 0.0420 | 1.0000 | 1.73 | 1.18 |
| Oesophagus | Tobacco: LM. Cannabis | 0.015 | 0.002 | 7.62 × 10−11 | 2.80 × 10−10 | 1.67 × 10−8 | 1.21 | 1.17 |
| Kidney | Tobacco: LM. Cannabis | 0.013 | 0.002 | 2.33 × 10−10 | 8.48 × 10−10 | 5.07 × 10−8 | 1.21 | 1.17 |
| Brain | Tobacco: LM. Cannabis: Herb. THC | 0.081 | 0.038 | 0.0308 | 0.0476 | 1.0000 | 1.71 | 1.15 |
| Thyroid | Alcohol | 0.027 | 0.011 | 0.0156 | 0.0258 | 1.0000 | 1.33 | 1.12 |
| Anus | Tobacco: LM. Cannabis | 0.006 | 0.001 | 6.92 × 10−5 | 0.0001 | 0.0110 | 1.16 | 1.11 |
| Non-Hodgkin’s Lymphoma | Tobacco: LM. Cannabis | 0.009 | 0.002 | 6.70 × 10−5 | 0.0001 | 0.0107 | 1.16 | 1.11 |
| Testis | Tobacco: LM. Cannabis: Herb. THC | 0.154 | 0.076 | 0.0422 | 0.0619 | 1.0000 | 1.69 | 1.09 |
| All Cancers | Tobacco: LM. Cannabis | 0.013 | 0.006 | 0.0307 | 0.0476 | 1.0000 | 1.31 | 1.08 |
| Cervix | Tobacco | 0.017 | 0.007 | 0.0192 | 0.0310 | 1.0000 | 1.17 | 1.06 |
Table key: β-Estimate—estimate of the regression coefficient; Std. Error—standard error of the regression coefficient; p-value—significance level; P. Adj. Holm—p-value adjusted for multiple testing by the method of Holm; Adj. P. FDR—p-value adjusted for multiple testing by the false discovery rate method of Benjamini and Hochberg; E-value—expected value required of some unknown confounder covariate with both the exposure and the outcome to explain the observed effect; lower bound of the E-value—the 95% lower bound of the confidence interval of the E-value.