Table 1.
The functions of human TSCM cell markers.
| CD marker(s) | Function(s) | Ref. |
|---|---|---|
| CD45RA+, CD45RO–, CD27+ | Are related to both memory and effector ability of TSCM cell | (4) |
| CCR7+, CD62L+ | Drive TSCM cell homing in SLO | (1, 2, 4) |
| CD57+ | 1) Telomere shortening (cell senescence) 2) Enhances degranulation ability 3) Enhances inflammatory cytokine secretion |
(4) |
| CD11α+, CD28+, CD58+ | T cell pan markers | (1–4) |
| CD44+/-, CD95+ | Distinguished markers among naive, effector, and memory T cells | (1–4, 11) |
| CD43- | Distinguished marker between effector and memory T cells | (4, 12) |
| CD122+, CXCR3+ | 1) Lead to higher proliferation, multipotency, and polyfunctionality 2) Augment the production of TNF-α, IFN-γ, and IL-2 by TSCM cell 3) CXCR3 also helps in TSCM cell LN homing |
(4) |
| CD127+ | Helps in TSCM cell survival and proliferation | (2, 4) |
SLO, secondary lymph organ; LN, lymph node; TNF-α, tumor necrosis factor-alpha; IFN-γ, interferon-gamma; IL-2, interleukin-2.