Table 1.
Baseline lab values.
| Lab Variables | Case 1 | Case 2 | Case 3 | Reference Range |
|---|---|---|---|---|
| WBC | 7.1 | 6.8 | 6.9 | 3.6–10.6 k/cumm |
| RBC | 4.62 | 4.61 | 4.62 | 3.71–5.17 million/cumm |
| Platelets | 438 | 310 | 339 | 150–450 k/cumm |
| MPV | 6.8 | 8.4 | 8.1 | 7–12 fL |
| PT/INR | 12.7/1.13 | 13.2/1.18 | - | 9.3–13.5 s/0.75–1.26 |
| aPTT | 35.1 | 35 | - | 23.4–38 s |
| TCT | 14.2 | - | - | 10.7–14.6 s |
| Fibrinogen | 336 | - | - | 170–399 mg/dL |
| Factor VIII assay | 187% | - | - | 61–155% |
| Factor XI assay | 125% | - | - | 77–162% |
| Factor XIII assay | 115% | - | - | 69–143% |
| vWF activity screen | 107% | - | - | 43–195% |
| vWF Ag | 109% | - | - | 44–167% |
| vWF collagen binding assay | 77% | - | - | 40–183% |
Cases 2 and 3 did not have complete work-ups as it was unnecessary for making the diagnosis. Abbreviations: WBC: white blood cells. RBC: red blood cells. MPV: mean platelet volume. PT: prothrombin time. aPTT: activated partial thromboplastin time. TCT: thrombin clotting time. vWF: von Willebrand factor.