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. 2023 Jul 13;12(3):47. doi: 10.3390/antib12030047

Figure 2.

Figure 2

MUC1/CD3 BsAb can induce potent T cell-mediated MUC1-expressing cell lysis. (A) Tumor cell lines: HeLa, MCF7, SKOV3, and NOZ were first stained by MUC1/CD3 BsAb and followed by a secondary FITC anti-human IgG Fc antibody. MUC1 expression was detected by flow cytometry. (B) Detection of tumor cell lysis after 48 h of incubation with human PBMCs (E/T 10:1) or T cells (E/T 5:1) with serially diluted antibodies. (C) Detection of T cell-mediated cytotoxicity in the presence of serially diluted antibodies with different E/T ratios (2:1 or 8:1) in human T cell and tumor cell co-culture cytotoxic assay.