Fig. 6.

TAF15 knockdown attenuated OA in ACLT mice. TAF15 was knocked down by adenovirus in ACLT-induced mouse model with knee OA (A) GREM1 protein level in mouse cartilage tissues was determined by Western blot (B–C) The number of MMP13-positive cells and Collagen II level in mouse cartilage tissues were examined using IHC (D–E) HE and Safranin O-stained sections were analyzed by three independent doctors blinded to the grouping, and the average scores were calculated (F) Histology analysis were employed to analyze the cartilage pathological changes. Data were expressed as mean ± SD. n = 5. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.