Table 2.

VET studies in liver transplant describing parameters for hemostatic interventions

Study	Study type	N	MELD (median)	Device	Reagents and/or test	Assay inflection points for interventions:
						Plasma	Cryoprecipitate/Fibrinogen	Platelets	Antifibrinolytic
Trzebicki et al38	Observational	39	17	ROTEM Delta	EXTEM, FIBTEM	Clotting time with EXTEM > 90 min	MCF with FIBTEM < 10	MCF with EXTEM < 50	Maximum lysis > 15%
Wang et al26	Randomized controlled trial	28	11	TEG 5000	Kaolin	Reaction time > 10 min	Angle <45°	Maximum amplitude < 50 mm	None reported
Roullet et al39	Observational	60	19	ROTEM Delta	EXTEM, FIBTEM	Not reported	Amplitude at 10 min with EXTEM < 26 mm; amplitude at 10 min with EXTEM ≥ 29 mm and with FIBTEM ≤ 8 mm	Amplitude at 10 min with EXTEM < 26 mm and with FIBTEM > 8 mm	“Hyperfibrinolysis present” with EXTEM or FIBTEM
De Pietri et al23	Observational	386	20	TEG 5000	Native, FF	Reaction time > 40 min and maximum amplitude with FF > 7 mm	Maximum amplitude < 30 mm and maximum amplitude with FF < 7 mm	Maximum amplitude < 30mm and maximum amplitude with FF > 7 mm	“Fibrinolysis present”
Smart et al28	Observational	68	28	ROTEM Delta	EXTEM, FIBTEM	Clotting time with EXTEM > 90 min	MCF with FIBTEM < 10	MCF with EXTEM < 50	Maximum lysis with EXTEM > 15%
Zamper et al27	Propensity matched	237	22	ROTEM Delta	INTEM, HEPTEM, EXTEM, FIBTEM	Clotting time with INTEM > 240 min and clotting time with HEPTEM ≥ clotting time with INTEM	Amplitude at 5 min with EXTEM < 25 mm and amplitude at 10 min with FIBTEM < 10 mm	Amplitude at 5 min with EXTEM < 25 mm and amplitude at 10 min with FIBTEM > 10 mm	Clot lysis index at 30 min with EXTEM < 50% after reperfusion
Bonnet et al25	Randomized controlled trial	81	16	ROTEM Delta	EXTEM, APTEM	Clotting time with EXTEM > 110 min	Amplitude at 10 min with FIBTEM < 10 mm	MCF with EXTEM < 40 mm or amplitude at 10 min < 35 mm and amplitude at 10 min with FIBTEM > 8 mm or MCF > 8 mm	Hyperfibrinolysis with EXTEM or maximum lysis < 15% and with APTEM < 10% clotting time or clot formation time > 15% MCF
Scarlatescu et al29	Propensity matched	188	19	ROTEM Delta	INTEM, HEPTEM, EXTEM, FIBTEM	Clotting time with INTEM > 280 min and clotting time with HEPTEM > 280 min	Amplitude at 10 min EXTEM < 25 mm and amplitude at 10 min FIBTEM < 8 mm	Amplitude at 10 min with EXTEM < 25 mm and amplitude at 10 min with FIBTEM > 8 mm	Clot lysis index at 60 min EXTEM < 85% in pre-anhepatic phase or clot lysis index at 30 min with EXTEM < 50% anhepatic phase or later
Gaspari et al40	Propensity matched	226	20	TEG 5000	Kaolin	Not reported	Angle < 55°	Maximum amplitude < 30 mm	Not reported

Abbreviations: FF, functional fibrinogen; MELD, Model for End-Stage Liver Disease score; N, population number; ROTEM, rotational thrombelastography; TEG, thrombelastography; VET, viscoelastic testing.