Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of hypofibrinolysis. Hypofibrinolysis occurs from either lack of release of plasminogen activators or increase basal expression of inhibitors, or a combination of both. This figure represents the multiple steps at which tPA release can be impaired from the endothelial cells and local neurons. Increased release of PAI-1 can occur in multiple cell lines, often due to cytokines and other stimuli. PAI-1, plasminogen activator inhibitor 1; tPA, tissue plasminogen activator.
